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Transfusion of modified whole blood versus blood components therapy in patients with severe trauma: Randomized controlled trial protocol (WEBSTER trial).
Injury
January 2025
División de Cirugía de Trauma y Emergencias, Departamento de Cirugía, Fundación Valle del Lili, Cali, Colombia; Departamento de Cuidado Intensivo, Fundación Valle del Lili, Cali, Colombia; Departamento de Cirugía, Universidad del Valle, Cali, Colombia.
Hemostatic resuscitation is a mainstay in the management of trauma patients. Factors such as blood loss and tissue injury contribute to coagulation and hemodynamic status imbalances. Hemorrhage remains a leading cause of death in trauma patients, despite advances in strategies such as damage control surgery, massive transfusion protocol, and intensive care.
View Article and Find Full Text PDFPretransplant Midodrine Use-A Risk Factor for Graft Loss at 1 Year in Kidney Transplant Recipients?
Transplant Proc
March 2025
Department of Surgery, Division of Transplantation, The Ohio State University Wexner Medical Center, Columbus OH.
Introduction: Hypotension is a frequent complication of patients who are on chronic maintenance hemodialysis. Midodrine is an alpha-1 adrenergic agonist used to treat patients on hemodialysis who have chronic hypotensiom. The aim of our study was to evaluate if patients who required midodrine for hypotension had inferior outcomes compared to those who did not require midodrine.
View Article and Find Full Text PDFAssociation between serum uric acid to high-density lipoprotein cholesterol ratio and all-cause and cardiovascular disease mortality after stroke: A cross-sectional study from 2005 to 2018.
Nutr Metab Cardiovasc Dis
February 2025
Department of Clinical Laboratory, Affiliated Liutie Central Hospital of Guangxi Medical University, Liuzhou, Guangxi, 545007, PR China. Electronic address:
Background And Aims: The uric acid to high-density lipoprotein cholesterol ratio (UHR) has been shown to be associated with multiple metabolic diseases and inflammation. Stroke is the second leading cause of death and the third leading cause of disability worldwide. This study investigated the relationship between serum UHR and mortality in adults with stroke.
View Article and Find Full Text PDFInstitutional toe & flow programs: How and why the teams work.
Semin Vasc Surg
March 2025
Center for Limb Preservation and Diabetic Foot, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA.
Diabetic foot ulcers with or without concomitant chronic limb-threatening ischemia put patients at exceedingly high risk of limb loss and death. The toe & flow model is a multidisciplinary team-based model captained by a podiatrist or orthopedic foot and ankle specialist and a vascular specialist, which streamlines treatment for patients with diabetic foot ulcer and chronic limb-threatening ischemia. This model creates a functional ecosystem around it by integrating other medical professionals and community partners.
View Article and Find Full Text PDFHypovolemic and hemorrhagic shock are life-threatening conditions that, if untreated, rapidly lead to multi-organ failure and death. These conditions result from significant intravascular fluid or blood loss, causing critical organ hypoperfusion. The underlying pathophysiology involves complex hemodynamic, inflammatory, and coagulation disturbances that may progress to irreversible organ dysfunction.
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