Secondary metabolites isolated from Piper chimonantifolium and their antifungal activity.

Nat Prod Res

Departamento de Ciências Exatas e da Terra, Universidade Federal de São Paulo, 09972-270, Diadema, SP, Brazil.

Published: August 2012

In this study, the CH(2)Cl(2) extract from leaves of Piper chimonantifolium was subjected to several chromatographic separation procedures to afford one chromene (gaudichaudianic acid) as a major compound as well as two flavonoids (dihydrooroxylin and pinocembrin) and three steroids (sitosterol, sitosteryl palmitate and stigmasterol). The structures of all determined compounds were characterised by spectrometric analysis, mainly mass spectrometry and NMR, as well as their optical properties. This article describes the first phytochemical study of the leaves of P. chimonantifolium and an evaluation of the antifungal activity of its major compounds.

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http://dx.doi.org/10.1080/14786419.2011.561435DOI Listing

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Secondary metabolites isolated from Piper chimonantifolium and their antifungal activity.

Nat Prod Res

August 2012

Departamento de Ciências Exatas e da Terra, Universidade Federal de São Paulo, 09972-270, Diadema, SP, Brazil.

In this study, the CH(2)Cl(2) extract from leaves of Piper chimonantifolium was subjected to several chromatographic separation procedures to afford one chromene (gaudichaudianic acid) as a major compound as well as two flavonoids (dihydrooroxylin and pinocembrin) and three steroids (sitosterol, sitosteryl palmitate and stigmasterol). The structures of all determined compounds were characterised by spectrometric analysis, mainly mass spectrometry and NMR, as well as their optical properties. This article describes the first phytochemical study of the leaves of P.

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