AI Article Synopsis
- Periodontal diseases are primarily caused by infections, and their effects depend on how the body responds to these infections.
- While certain unusual forms of these diseases have been linked to genetics, they only represent a small fraction of patients with periodontal issues.
- Most periodontal cases show little strong evidence of genetic factors, so research is focused on identifying specific genes that contribute to these conditions without being influenced by environmental factors.
Article Abstract
Periodontal diseases are essentially infectious in origin, their outcome depending on interaction between the pathogenic challenge and host response. Host genotype has been implicated in certain of the more unusual forms, but together these account for only a small proportion of periodontal patients. Nevertheless, the genes for these rarer conditions, some of which have already been located and/or cloned, are of considerable importance, since they may ultimately provide clues leading to a better understanding of the whole spectrum of periodontal disease. For the majority of periodontal patients, although inherited susceptibility is suspected, evidence of a significant genetic component is scanty. The priority here is therefore to establish the existence of contributing genes. This may be possible by using approaches designed to minimise the confounding effect of environmental variation that has probably been a source of confusion in the past.
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| http://dx.doi.org/10.1111/j.1600-051x.1990.tb02337.x | DOI Listing |
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