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Laboratory Evaluation of the Effectiveness of Pathogen Reduction Procedures for Bacteria. | LitMetric

Laboratory Evaluation of the Effectiveness of Pathogen Reduction Procedures for Bacteria.

Transfus Med Hemother

DRK-Blutspendedienst NSTOB, Institut Springe, Langen, Germany.

Published: July 2011

AI Article Synopsis

  • - Bacterial contamination in blood transfusions can lead to serious health issues, making pathogen reduction procedures essential for keeping blood components, especially platelets, safe from infection.
  • - Traditional methods to evaluate the effectiveness of these procedures involved measuring how much the bacterial count decreases after treatment, similar to testing antiviral activities.
  • - Newer testing protocols are being developed to monitor bacteria throughout the entire storage period of blood, and comparing results from various pathogen reduction technologies highlights the need for standardized bacterial reference strains to improve experimental reliability.

Article Abstract

SUMMARY: Bacterial contamination remains a leading factor for transfusion-associated serious morbidity and mortality. Pathogen reduction procedures offer a pro-active approach to prevent bacterial contamination of cellular blood components and especially of platelet concentrates. In the past, the laboratory evaluation of the effectiveness of the pathogen reduction procedures to minimise the bacterial load of blood components has been primarily based on log reduction assays similar to the assessment of antiviral activities. Bacteria strains with the ability to multiply in the blood components are seeded in highest possible cell numbers, the pathogen reduction procedure is applied, and the post-treatment number of bacteria is measured. The effectiveness of the procedure is characterised by calculating the log reduction of the post- to pre-treatment bacteria titres. More recently, protocols have been developed for experiments starting with a low bacteria load and monitoring the sterility of the blood component during the entire storage period of the blood component. Results for 3 different pathogen reduction technologies in these experimental models are compared and critical determinants for the results are addressed. The heterogeneity of results observed for different strains suggests that the introduction of international transfusion-relevant bacterial reference strains may facilitate the validity of findings in pathogen reduction experiments.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190220PMC
http://dx.doi.org/10.1159/000330338DOI Listing

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