The mechanistic basis of how cells respond to increased fatty acids (FAs) is murky but potentially involves receptor-mediated activation or inhibition by different FA classes. Holzer et al. (2011) recently propose in Cell that expansion of intracellular membrane microdomains induced by saturated FA recruit and activate c-Src for JNK activation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541012 | PMC |
| http://dx.doi.org/10.1016/j.devcel.2011.10.001 | DOI Listing |
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