Background: Polymorphisms of serotonin transporter (5-HTT) and brain-derived neurotrophic factor (BDNF) have been investigated as candidate genes for post-stroke depression (PSD). Serotonin 2a receptor (5-HTR2a) genes have not been yet investigated in PSD. This study aimed to investigate whether the 5-HTT, 5-HTR2a, and BDNF genes are associated with PSD independently and/or interactively in a Korean sample with high prevalence of risk alleles.
Methods: In 276 stroke cases, depression was diagnosed using DSM-IV at 2 weeks after stroke, further classified to major PSD (N=29), all (major plus minor) PSD (N=77), and control (N=199) groups. Associations between PSD and 5-HTTLPR, STin2 VNTR, 5-HTR2a 1438A/G, 5-HTR2a 102T/C, and BDNF val66met genotypes were estimated using logistic regression models, and gene-gene interactions were investigated using the generalized multifactor dimensionality reduction method.
Results: 5-HTR2a 1438 A/A genotype was associated with major PSD, while 5-HTTLPR s/s and BDNF met/met genotypes were associated with all PSD. There was a significant interaction between 5-HTR2a 1438A/G and BDNF val66met polymorphisms for major PSD and a borderline significant interaction between 5-HTTLPR and BDNF val66met polymorphisms for all PSD.
Conclusions: In a large cohort, we found evidence for serotonin and BDNF polymorphisms as susceptibility factors and gene-gene interactions between these systems for depression at 2 weeks post-stroke.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jad.2011.09.029 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characteristics of Gut Microbiota and Plasma Metabolites in Patients with Post-Stroke Depression.
Neuropsychiatr Dis Treat
March 2025
Neurology Department, Xuanwu Hospital of Capital Medical University, Beijing, People's Republic of China.
Purpose: The changes in gut microbiota and plasma metabolites have been proposed to play a key role in post stroke depression (PSD), but clinical study based on combined omics is still in lack. This study aimed to investigate the characteristics of gut microbiota and plasma metabolites in patients 3 months after the onset of acute ischemic stroke (AIS), compare PSD and non-PSD groups, and explore possible diagnostic biomarkers.
Patients And Methods: Seventy patients with stroke were included at 3 months after AIS onset.
Plasma polyamines levels and post-stroke depression in ischemic stroke patients: A multicenter prospective study.
Atherosclerosis
February 2025
Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu Province, 215123, China; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1430 Tulane Ave, SL 18, New Orleans, LA, 70112, USA. Electronic address:
Background And Aims: Polyamines have been suggested to implicated in inflammation, ischemic stroke, and mental disorders, but the associations of polyamines with post-stroke depression (PSD) remain unclear. We aimed to prospectively investigate the associations of plasma putrescine, spermidine and spermine with PSD among ischemic stroke patients in a multicenter cohort study.
Methods: We measured plasma putrescine, spermidine and spermine levels at baseline among 635 ischemic stroke patients from a preplanned ancillary study of the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke).
Brain dynamics alterations induced by partial sleep deprivation: An energy landscape study.
Neuroimage
March 2025
Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology, Xi'an Jiaotong University, Key Laboratory of Neuro-informatics & Rehabilitation Engineering of Ministry of Civil Affairs, Xi'an, Shaanxi, 710049, China; Research Center for Brain-inspired Intelligence, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China. Electronic address:
Partial sleep deprivation (PSD) alters neural activity of intrinsic brain networks involved in cognitive functions. However, the age-related time-varying properties of large-scale brain functional networks after PSD remain unknown. Our study applied energy landscape analysis to resting-state functional magnetic resonance imaging data to characterize the dominant brain activity patterns in 36 healthy young (19 females, 23.
View Article and Find Full Text PDFImplementation of Medication-related Technology and Its Impact on Pharmacy Workflow: A Real-World Evidence Study from 2017 to 2023.
J Med Internet Res
February 2025
Department of Pharmacy, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung City, TW.
Background: Medication errors constitute a major contributor to patient harm, driving up healthcare costs and representing a preventable cause of medical incidents. Over the past decade, many hospitals have integrated various medication-related technologies into their pharmacy operations. However, real-world evidence on the impact of these advanced systems on clinical prescription dispensing error rates remains limited.
View Article and Find Full Text PDFNovel production of ultrafine particles to meet environmental and energy sustainability.
J Environ Manage
March 2025
School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 10081, China. Electronic address:
The production of ultrafine particles is increasingly important, but requires special attention to mitigate environmental and energy burdens. Among available milling equipment, the air-jet mill (AJM) has major merits. AJM is applied in the pharmaceutical, catalyst, and ceramic industries to produce μm-particles with high specific surface area, high catalytic activity, and effective ad/absorbent properties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!