Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190524 | PMC |
| http://dx.doi.org/10.4103/0019-5049.84843 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reversible cerebral vasoconstriction syndrome in a methylphenidate-treated patient: a case report.
BMC Neurol
December 2024
Pharmacovigilance, Pharmacoepidemiology and Drug Information Centre, Department of Clinical Pharmacology, Rennes University Hospital, Rennes, 35033, France.
Background: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by severe headaches, often thunderclap headaches, and a multifocal constriction of the cerebral arteries. Although RCVS can occur spontaneously, some cases occur after exposure to drugs. We describe the first case of RCVS in which methylphenidate, a drug with vasoconstrictive properties, is the only suspected drug.
View Article and Find Full Text PDFDepression of Ca1.2 activation and expression in mast cells ameliorates allergic inflammation diseases.
J Pharm Anal
November 2024
Department of Pharmaceutical Analysis, School of Pharmacy, Xi'an Jiaotong University, Xi'an, 710061, China.
Allergic inflammation is closely related to the activation of mast cells (MCs), which is regulated by its intracellular Ca level, but the intake and effects of the intracellular Ca remain unclear. The Ca influx is controlled by members of Ca channels, among which calcium voltage-gated channel subunit alpha1 C (Ca1.2) is the most robust.
View Article and Find Full Text PDFVoltage-sensitive calcium channels contribute to depolarization of both motor- and interneurons in animal studies, but less is known of their contribution to human motor control and whether blocking them has potential in future antispasmodic treatment in humans. Therefore, this study investigated the acute effect of Nimodipine on the transmission of human spinal reflex pathways involved in spasticity. In a double-blinded, cross-over study, we measured soleus muscle stretch- and H-reflexes, and tibialis anterior cutaneous reflexes in nineteen healthy subjects before and after Nimodipine (tab-let 60mg) or Baclofen (tablet 25mg).
View Article and Find Full Text PDFDeciphering the peculiarities of cell types in the septum.
Neuroscience
November 2024
Center for Biomedical Studies, Department of Biological Sciences, University of Texas at Brownsville, TX 78520, USA; Laboratory of Emotions' Neurobiology, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Poland; Instituto de Medicina Molecular, Universidade de Lisboa, Lisbon 1649, Portugal; Institute of Biophysics, Johannes Kepler University, Linz, Austria. Electronic address:
Similar to other brain regions, the neurons in the lateral septum (LS) are of heterogeneous populations. However, their resting membrane potential (RMP) on average is not too far apart. Cells were characterized based on biological markers by using brain slices, as under these in vitro conditions, neurons retain their morphologies.
View Article and Find Full Text PDFEllipsoid Zone Reflectivity: Exploring its Potential as a Novel Non-Invasive Biomarker for Assessing Mitochondrial Function.
Neuroophthalmology
June 2024
Department of Brain Repair and Rehabilitation, Moorfields Eye Hospital NHS Foundation Trust, UCL, London, UK.
Article Synopsis
- The ellipsoid zone (EZ) on macular optical coherence tomography (OCT) scans shows high intensity due to dense mitochondria, potentially indicating mitochondrial function and offering insights into eye diseases.
- A new analysis tool was developed to measure EZ reflectivity in patients with optic neuritis and other optic neuropathies compared to healthy individuals, revealing reliable ratios that indicate differences in reflectivity.
- Results suggest that EZ reflectivity is lower in certain neuroinflammatory and mitochondrial disorders, indicating its potential as a non-invasive biomarker for mitochondrial health, but further research is needed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!