Septic peritonitis is an inflammatory condition of the peritoneum that has a wide variety of clinical courses. The etiology and pathophysiology of this condition and its diagnosis in small animals are reviewed in a companion article. This article addresses the treatment of septic peritonitis and prognosis in small animals.
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Despite intensive clinical and scientific efforts, the mortality rate of sepsis remains high due to the lack of precise biomarkers for patient stratification and therapeutic guidance. Interleukin 40 (IL-40), a novel cytokine with immune regulatory functions in human diseases, was elevated at admission in two independent cohorts of patients with sepsis. High levels of secreted IL-40 in septic patients were positively correlated with PCT, CRP, lactate (LDH), and Sequential Organ Failure Assessment (SOFA) scores, in which IL-40 levels were used to stratify the early death of critically ill patients with sepsis.
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3State Higher Medical College named after D. Kalmataev, Semey, Republic of Kazakhstan.
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