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Method Evaluation of the QuidelOrtho Diagnostics Vitros NT-proBNP II Assay.
J Clin Med
December 2024
Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, 4650 Sunset Blvd, M/S #32, Los Angeles, CA 90027, USA.
N-terminal-proBNP (NT-proBNP) is a biomarker released into the blood in response to heart failure, reflecting the extent of cardiac stress and damage. QuidelOrtho Diagnostics released its latest reformulation of its NT-proBNP assay, the Vitros NT-proBNP II assay. This study aims to evaluate the analytical performance of the Vitros NT-proBNP II assay.
View Article and Find Full Text PDFImpact of administration routes and dose frequency on the toxicology of SARS-CoV-2 mRNA vaccines in mice model.
Arch Toxicol
December 2024
Department of Experiment Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
The increasing use of SARS-CoV-2 mRNA vaccines has raised concerns about their potential toxicological effects, necessitating further investigation to ensure their safety. To address this issue, we aimed to evaluate the toxicological effects of SARS-CoV-2 mRNA vaccine candidates formulated with four different types of lipid nanoparticles in ICR mice, focusing on repeated doses and administration routes. We conducted an extensive analysis in which mice received the mRNA vaccine candidates intramuscularly (50 μg/head) twice at 2-week intervals, followed by necropsy at 2 and 14 dpsi (days post-secondary injection).
View Article and Find Full Text PDFDengue Cardiomyopathy Treatment Strategy Optimisation by Integrating Point of Care Ultrasound (POCUS) with VExUS.
POCUS J
November 2024
Medical Department, Limbang Hospital Sarawak MYS.
Dengue fever is an arthropod-borne viral disease that is widespread throughout the world. We report a case of dengue cardiomyopathy that was detected and treated to best effect using point of care ultrasound (POCUS) and the VExUS score. A 75-year-old lady with no known comorbidities presented with a ten-day history of fever, vomiting, loose stool, and poor appetite.
View Article and Find Full Text PDFDeterioration in Renal Function in Patients With a Fontan Circulation and Association With Mortality.
JACC Adv
December 2024
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Article Synopsis
- Renal dysfunction is common in patients with Fontan circulation, with 12% showing renal issues based on eGFR measurements, and 24% based on cystatin C levels.
- Over an 11-year study, these patients experienced a faster decline in renal function compared to healthy individuals, averaging a drop of 1.36 ml/min/1.73 m/year.
- Higher levels of NT-proBNP at the start were linked to quicker drops in renal function, and worsened renal function over time was associated with increased mortality rates.
Low-dose dobutamine in acute myocardial infarction with intermediate to high risk of cardiogenic shock development (the DOBERMANN-D trial): study protocol for a double-blinded, placebo-controlled, single-center, randomized clinical trial.
Trials
October 2024
Department of Cardiology, The Heart Centre, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 2142, Copenhagen, DK-2100, Denmark.
Article Synopsis
- Cardiogenic shock (CS) affects 5-10% of acute myocardial infarction (AMI) patients and has a high 30-day mortality rate, with many patients showing signs of risk upon hospital arrival, highlighting the need for effective prevention strategies.
- The study aims to determine if administering low-dose dobutamine after revascularization can prevent hemodynamic instability in AMI patients at risk for in-hospital CS.
- A clinical trial will involve 100 patients, comparing dobutamine's effects on biomarkers and hemodynamic parameters to a placebo, with outcomes measured over several days to assess cardiac function.
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