Delirium (acute confusional state) is one of the most common mental disorders encountered in patients with medical illness, particularly among those who are older. It is associated with many complex underlying medical conditions and can be hard to recognise. Systematic studies and clinical trials are difficult to perform in patients with cognitive impairment; recommendations for evaluating and treating delirium are based primarily upon clinical observation and expert opinion. Our knowledge of the clinical epidemiology of delirium has substantially increased in the last decade, providing a basic framework for understanding and managing the disorder.
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Drug Development.
Alzheimers Dement
December 2024
University of Kentucky Sanders-Brown Center on Aging, Lexington, KY, USA.
Background: The presence of multiple comorbid pathologic features in late-onset dementia has been well documented across cohort studies that incorporate autopsy evaluation. It is likely that such mixed pathology potentially confounds the results of interventional trials that are designed to target a solitary pathophysiologic mechanism in Alzheimer's disease and related dementias (ADRD).
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Alzheimers Dement
December 2024
Korea Institute of Science and Technology, Seoul, Korea, Republic of (South).
Background: Elevation of cerebrospinal fluid (CSF) tau is a feature of Alzheimer's disease (AD) and is being explored as a biomarker of AD and other tauopathies. The aim of this study was to elucidate the in vivo effects of DA-7503, a potent and selective tau aggregation inhibitor, and its pharmacodynamics on CSF tau in transgenic mouse models of Alzheimer's disease and primary tauopathies.
Method: TauP301L-BiFC mice expressing full-length human tau with the P301L mutation were orally administrated with DA-7503 for 1 month.
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