AI Article Synopsis
- Reactivating memories can make them vulnerable to change, leading to potential erasure through extinction training, which works for both fear and food-related memories.
- Administering the NMDA receptor partial agonist D-cycloserine didn't enhance the extinction of appetitive memories, indicating that memory reactivation doesn't always boost extinction learning.
- Blocking contextual memory reactivation with nimodipine affects the memory disruption outcome, showing that behavioral strategies can manipulate the reconsolidation process for both negative and positive memories.
Article Abstract
The reactivation of a memory through retrieval can render it subject to disruption or modification through the process of memory reconsolidation. In both humans and rodents, briefly reactivating a fear memory results in effective erasure by subsequent extinction training. Here we show that a similar strategy is equally effective in the disruption of appetitive pavlovian cue-food memories. However, systemic administration of the NMDA receptor partial agonist D-cycloserine, under the same behavioural conditions, did not potentiate appetitive memory extinction, suggesting that reactivation does not enhance subsequent extinction learning. To confirm that reactivation followed by extinction reflects a behavioural analogue of memory reconsolidation, we show that prevention of contextual fear memory reactivation by the L-type voltage-gated calcium channel blocker nimodipine interferes with the amnestic outcome. Therefore, the reconsolidation process can be manipulated behaviourally to disrupt both aversive and appetitive memories.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516828 | PMC |
| http://dx.doi.org/10.1038/ncomms1515 | DOI Listing |
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