Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/ajh.2011.135 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Angiotensin 1-7 Attenuates the Development of Ischemia-Reperfusion-Induced Arrhythmia in Rats: Electrophysiology, Molecular, and Immunohistochemical Study.
Microsc Res Tech
January 2025
Department of Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Arrhythmia is a common and serious global health problem, contributing to cardiovascular morbidity and mortality. The cardiac muscle is susceptible to ischemia-reperfusion (I/R) injury, which can lead to fatal arrhythmias during open-heart surgery. We investigated the potential prophylactic effect of angiotensin 1-7 (Ang 1-7) using an in vivo rat model of I/R injury and examined the underlying mechanisms.
View Article and Find Full Text PDFImpact of COVID-19 infection on cyclooxygenase-2 gene expression and mast cell count in testicular tissue of azoospermic men.
Cell Mol Biol (Noisy-le-grand)
December 2024
Epidemiology, Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Article Synopsis
- * This research focused on 41 men undergoing testicular sperm extraction, comparing those infected with COVID-19 to non-infected individuals, specifically examining inflammatory proteins like mast cells and COX-2 in testicular tissue.
- * Results revealed that COVID-19-infected men had higher levels of COX-2 expression and more mast cells, indicating heightened inflammation in their testicular tissue, which may negatively affect male fertility.
Pharmaceutical Modulation of Intracranial Aneurysm Development and Rupture.
J Clin Med
June 2024
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Management of intracranial aneurysms (IAs) is determined by patient age, risk of rupture, and comorbid conditions. While endovascular and microsurgical interventions offer solutions to mitigate the risk of rupture, pharmacological management strategies may complement these approaches or serve as alternatives in appropriate cases. The pathophysiology of IAs allows for the targeting of inflammation to prevent the development and rupture of IAs.
View Article and Find Full Text PDFVicinal diaryl pyrazole with tetrazole/urea scaffolds as selective angiotensin converting enzyme-1/cyclooxygenase-2 inhibitors: Design, synthesis, anti-hypertensive, anti-fibrotic, and anti-inflammatory.
Drug Dev Res
June 2024
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
As a hybrid weapon, two novel series of pyrazoles, 16a-f and 17a-f, targeting both COX-2 and ACE-1-N-domain, were created and their anti-inflammatory, anti-hypertensive, and anti-fibrotic properties were evaluated. In vitro, 17b and 17f showed COX-2 selectivity (SI = 534.22 and 491.
View Article and Find Full Text PDFNon-steroidal anti-inflammatory drugs, renin-angiotensin system blockade or diuretics and risk of acute kidney injury: A case-crossover study.
Arch Gerontol Geriatr
August 2024
Department of Cardiology, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan. Electronic address:
Background: Aging-related physiological changes, such as decline in renal function, not only exacerbates pre-existing comorbidities but also escalate the susceptibility to adverse events. Previous studies have shown that non-steroidal anti-inflammatory drugs (NSAIDs) are associated with an increased risk of acute kidney injury (AKI), and the concomitant use of renin-angiotensin system blockade or diuretics may further potentiate the risk. However, studies evaluating the risk of AKI associated with NSAIDs (including routes, concomitant use of different NSAIDs, categories (traditional NSAIDs or COX-2 inhibitors), and cumulative doses of NSAIDs) are limited, particularly the risk of AKI associated with the dual or triple combination of NSAIDs with renin-angiotensin system blockade (RAS blockades) and/or diuretics.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!