AI Article Synopsis
- The study investigated the impact of inhaling vanadium pentoxide (V(2)O(5)) on platelet function in mice, as well as its effects on human platelets in lab tests.
- Mouse blood tests showed that platelet aggregation was inhibited during four weeks of exposure, but returned to normal levels after eight weeks, even after stopping exposure.
- P-selectin levels remained stable during exposure, but increased after four weeks without further exposure, indicating that vanadium does affect platelet function and more research is needed on its overall impact on the hemostatic system.
Article Abstract
Vanadium pentoxide (V(2)O(5)) inhalation effect on platelet function in mice was explored, as well as the in vitro effect on human platelets. Mouse blood samples were collected and processed for aggregometry and flow cytometry to assess the presence of P-selectin and monocyte-platelet conjugates. Simultaneously, human platelets were processed for aggregometry(.) The mouse results showed platelet aggregation inhibition in platelet-rich-plasma (PRP) at four-week exposure time, and normality returned at eight weeks of exposure, remaining unchanged after the exposure was discontinued after four weeks. This platelet aggregation inhibition effect was reinforced with the in vitro assay. In addition, P-selectin preserved their values during the exposure, until the exposure was discontinued during four weeks, when this activation marker increased. We conclude that vanadium affects platelet function, but further studies are required to evaluate its effect on other components of the hemostatic system.
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| http://dx.doi.org/10.1016/j.etap.2011.08.010 | DOI Listing |
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