AI Article Synopsis
- A new microwave-assisted method has been created for the direct alkenylation of purines using palladium and copper as co-mediators.
- The process is efficient, selective about where it acts on the molecule, and works well with various functional groups and similar compounds.
- This technique allows for the easy creation of new types of complex purines with multiple substitutions.
Article Abstract
An efficient microwave-assisted palladium/copper comediated C-8 direct alkenylation of purines with styryl bromides has been developed. The method is regioselective, functional group tolerant, rapid, and compatible with other related azoles. Combined with subsequent nucleophilic substitution, it provides an easy access to new 6,8,9-trisubstituted purines.
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| http://dx.doi.org/10.1021/jo201893h | DOI Listing |
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