AI Article Synopsis
- Eight new diterpenoids named klymollins A-H were discovered from the soft coral Klyxum molle found in Taiwan.
- Their chemical structures were determined using detailed spectroscopic techniques, with the configuration of one specific compound established through Mosher's method.
- Bioassays indicated that most of these new compounds (3-8) have significant anti-inflammatory effects, particularly by inhibiting iNOS and reducing COX-2 protein levels in stimulated macrophage cells.
Article Abstract
Eight new eunicellin-based diterpenoids, klymollins A-H (1-8), were isolated during the chemical investigation of the soft coral Klyxum molle from Taiwan waters. Their structures were elucidated by extensive spectroscopic analysis. The absolute configuration of 4 was determined by Mosher's method. Bioassays of the new metabolites showed that compounds 3-8 displayed significant in vitro anti-inflammatory activity by inhibiting the expression of the iNOS protein, and compounds 3, 4, and 6-8 also could effectively reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/np200589n | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Klymollins A-H, bioactive eunicellin-based diterpenoids from the formosan soft coral Klyxum molle.
J Nat Prod
November 2011
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan, Republic of China.
Article Synopsis
- Eight new diterpenoids named klymollins A-H were discovered from the soft coral Klyxum molle found in Taiwan.
- Their chemical structures were determined using detailed spectroscopic techniques, with the configuration of one specific compound established through Mosher's method.
- Bioassays indicated that most of these new compounds (3-8) have significant anti-inflammatory effects, particularly by inhibiting iNOS and reducing COX-2 protein levels in stimulated macrophage cells.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!