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The most disastrous heatwaves are very extreme events with return periods of hundreds of years, but traditionally, climate research has focussed on moderate extreme events occurring every couple of years or even several times within a year. Here, we use three Earth System Model large ensembles to assess whether very extreme heat events respond differently to global warming than moderate extreme events. We find that the warming signal of very extreme heat can be amplified or dampened substantially compared to moderate extremes.

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Anorectal Botulinum Toxin Injection in Functional Constipation - The Jury is Still Out.

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January 2025

Department of Gastroenterology, Hepatology and Liver Transplant, Queensland Children's Hospital, Brisbane, Australia. Electronic address:

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Treatment failure and the threshold of disease extinction.

Infect Dis Model

June 2025

Department of Mathematics, Faculty of Science, Silpakorn Universtiy, Nakhon Pathom Province, 73000, Thailand.

Antibiotic treatment failure related to carriers poses a serious problem to physicians and epidemiologists. Due to the sparsity of data, assessing the role in infection dynamics is difficult. In this study, we examined the possibility that a particular therapeutic effectiveness will be regarded as the disease extinction threshold through the mathematical modelling approach.

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