AI Article Synopsis
- Tip-enhanced Raman spectroscopy (TERS) was utilized to analyze the distribution of two thiols, 2-mercaptopyridine (2-PySH) and 4-mercaptopyridine (4-PySH), in a self-assembled monolayer on a gold surface.
- The technique provided full spectral information for each pixel in an image taken from a microcontact-printed sample, confirming the expected molecular distribution.
- Specific spectral markers allowed for the localization of both isomers and semi-quantitative data was gathered, demonstrating TERS's ability to detect very weakly scattering analytes that normal Raman spectroscopy couldn't identify.
Article Abstract
Full spectroscopic imaging by means of tip-enhanced Raman spectroscopy (TERS) was used to measure the distribution of two isomeric thiols (2-mercaptopyridine (2-PySH) and 4-mercaptopyridine (4-PySH)) in a self-assembled monolayer (SAM) on a gold surface. From a patterned sample created by microcontact printing, an image with full spectral information in every pixel was acquired. The spectroscopic data is in good agreement with the expected molecular distribution on the sample surface due to the microcontact printing process. Using specific marker bands at 1000 cm(-1) for 2-PySH and 1100 cm(-1) for 4-PySH, both isomers could be localized on the surface and semi-quantitative information was deduced from the band intensities. Even though nanometer size resolution information was not required, the large signal enhancement of TERS was employed here to detect a monolayer coverage of weakly scattering analytes that were not detectable with normal Raman spectroscopy, emphasizing the usefulness of TERS.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190621 | PMC |
| http://dx.doi.org/10.3762/bjnano.2.55 | DOI Listing |
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