AI Article Synopsis
- The review examines how Parkinson's disease (PD) is related to stress and depression, highlighting the increased risk of depression in PD patients.
- Stress might play a role in the development of both PD and depression, potentially affecting early non-motor symptoms and worsening motor symptoms as the disease progresses.
- The study emphasizes the need for more research on the impact of stress and depression on neurodegeneration in PD, as there are relatively few existing studies in this area.
Article Abstract
In this review, we focus on the relationship among Parkinson's disease (PD), stress and depression. Parkinson's disease patients have a high risk of developing depression, and it is possible that stress contributes to the development of both pathologies. Stress dysfunction may have a role in the etiology of preclinical non-motor symptoms of PD (such as depression) and, later in the course of the disease, may worsen motor symptoms. However, relatively few studies have examined stress or depression and the injured nigrostriatal system. This review discusses the effects of stress on neurodegeneration and depression, and their association with the symptoms and progression of PD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268878 | PMC |
| http://dx.doi.org/10.1016/j.expneurol.2011.09.035 | DOI Listing |
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