AI Article Synopsis
- Oral verrucous carcinoma (OVC) is a low-grade form of squamous cell carcinoma, typically affecting elderly patients, and is characterized by its distinct morphology and behavior.
- Resection is the preferred treatment, while radiotherapy is also a viable option; however, this study focuses on 12 patients who could not undergo conventional treatment due to the seriousness of their lesions and overall health.
- Chemotherapy with methotrexate, administered in various ways and doses, proved beneficial for 11 out of 12 patients, suggesting it can reduce side effects and enhance quality of life, especially in older adults.
Article Abstract
Oral verrucous carcinoma (OVC) is a low-grade variant of squamous cell carcinoma (SCC) with a distinctive morphology and specific pattern of behaviour that is often diagnosed in elderly patients. Resection is the treatment of choice, with radiotherapy as a reasonable alternative. In this retrospective case review we present our experience and outcomes in a group of 12 patients with various stages of OVC who had not been treated conventionally because of the extent of their lesions and their poor general condition. All patients were given chemotherapy with methotrexate, which was given by various routes and in different doses during the period 1972-2010. In 11 patients treatment with methotrexate alone was beneficial. One patient failed to respond. Methotrexate used alone as chemotherapy may minimise morbidity and improve quality of life, particularly among elderly patients.
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| http://dx.doi.org/10.1016/j.bjoms.2011.09.011 | DOI Listing |
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