Introduction: Hypopharynx is the anatomical region created by strictly functionally connected regions: two pyriform sinuses, retrocricoid region and the posterior pharyngeal wall on its level. Hypopharyngeal Cancer is in 95% planoepithelial carcinoma, it constitute about 5-10% of all malignant tumors of the upper part of digestive tract and the respiratory system. Occult early symptoms make it advanced stages detectible. It easily spreads in to surrounding anatomical structures such as: larynx, oral cavity, oropharynx, esophagus, prevertebral space. It gives relatively quick and common metastases to lymph nodes (opposed or both sites).
Aim: The aim of our study is to analyze the complications of the advanced hypopharyngeal tumor surgery.
Material And Methods: Material was 53 patients treated for advanced hypopharyngeal cancer (or hypopharyngeal cancer with larynx and cervical part of esophagus involved), in Otolaryngology Clinic, Medical University of Warsaw, between 1999 and 2010. We performed the circular removal of hypopharynx, cervical part of esophagus and larynx with concomitant digestive tract reconstruction by autotransplantation of the jejunum (41 cases) or the ileocecal segment (12 cases). In most cases surgery was extended to lymph nodes removal.
Conclusion: In our group of patients we had complications such as: Intraoperative complications of surgery - the intestine transplant ischemia. Early post operative complications - transplant ischemia, salivary fistula, hematoma of postoperative cavity (without necrosis of the transplant), massive arterial anastomosis bleeding, and wound infection. Late postoperative complications - late salivary fistula, tracheostomy stenosis, local tumor recurrence, spread of the cancer and swallowing disorder. The different complications were very uncommon.
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http://dx.doi.org/10.1016/S0030-6657(11)70712-0 | DOI Listing |
Radiol Case Rep
March 2025
Department of Otorhinolaryngology Head and Neck Surgery, Charles Nicolle Hospital, Tunis, Tunisia.
Tracheal adenoid cystic carcinoma is a rare malignancy. We report the case of a 65-year-old male who presented to our department due to a 3-month history of mild dysphagia without other associated symptoms. The neck, laryngeal, and hypopharyngeal examinations were normal.
View Article and Find Full Text PDFTher Adv Med Oncol
January 2025
Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089 Rozzano, Italy.
Objectives: A combination of chemotherapy and radiotherapy is employed in the curative and postoperative treatment of locally advanced head and neck cancers (HNC). Integrated chemoradiation (CRT) treatments result in a non-negligible rate of severe toxic effects. Treatment-related death (TRD) is a crucial topic for physicians involved in the curative treatment of HNC.
View Article and Find Full Text PDFMol Carcinog
January 2025
Department of Otorhinolaryngology, The Third Affiliated Hospital of ZunYi Medical University/First People's Hospital of Zunyi, Zunyi, China.
This study aimed to explore PTPN2 expression levels in Hypopharyngeal Squamous Cell Carcinoma (HPSCC) tissues and their relationship with the clinical characteristics and prognosis of HPSCC patients. PTPN2, a protein tyrosine phosphatase, has recently emerged as a promising target for cancer immunotherapy, and in many previous studies, PTPN2 may have a significant role in the growth, differentiation, metabolism and immune response of head and neck malignant tumors. In this study, PTPN2 expression in Head and Neck Squamous Cell Carcinoma (HNSCC) and other cancer tissues was analyzed using datasets derived from the Sangerbox database.
View Article and Find Full Text PDFFront Oncol
December 2024
Clinic for Otorhinolaryngology, University Hospital Leipzig, Leipzig, Germany.
Introduction: The larynx organ preservation (LOP) trial DeLOS-II enrolled = 173 patients with advanced laryngeal/hypopharyngeal squamous cell carcinoma (LHSCC) amenable (only curatively resectable) through total laryngectomy (TL) to receive induction chemotherapy (IC) with TPF [docetaxel (T), cisplatin (P), and 5-fluorouracil (F)] (arm A, 85 patients) or additional cetuximab (E) weekly (arm B, 88 patients). Responders with endoscopic estimated tumor surface shrinkage (ETSS) ≥30% after 1 cycle IC (IC-1) received a further two cycles of IC followed by radiotherapy (RT), whereas TL was recommended for non-responders. Arm B failed to show superior 24-month laryngectomy-free survival (LFS) and overall survival (OS), the protocol-specified primary and secondary endpoints.
View Article and Find Full Text PDFJCO Glob Oncol
January 2025
Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Purpose: The incidence and survival rates of head and neck squamous cell carcinoma (HNSCC) and nasopharyngeal carcinoma (NPC) vary globally, influenced by factors such as ethnicity, lifestyle, and health care systems.
Methods: A retrospective analysis was conducted on patients with HNSCC treated between 2008 and 2020 in four major Thai academic cancer centers, using a multidisciplinary multicenter database. The study focused on the evolution of patient characteristics, survival changes, and treatment landscape alterations over time.
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