Triclosan is a chlorinated phenol ether that has been in widespread use as a broad-spectrum antibacterial agent for four decades. When compared to the limited international data available on human body burden of triclosan, results from a pooled blood study suggested that triclosan concentrations in Australia were a factor two higher than observed in Sweden. This study determined triclosan levels in individual human milk samples (n=151) collected between 2002 and 2005 from primiparous Australian mothers. It provided the first report of population triclosan levels and individual variation in Australia and gave a measure of infant exposure via breast feeding. The distribution of triclosan concentration was positively skewed, with 7.2% of the samples below the LOQ, 66% with a concentration of less than or equal to 1.0 ng g(-1)fresh weight and the remaining samples above 1 ng g(-1) reaching a maximum concentration of 19 ng g(-1)fresh weight. The mean and median triclosan concentrations were 1.3±2.7 ng g(-1)f.w. and 0.26 ng g(-1)f.w., respectively. The results of this study showed high variability in triclosan concentrations between individuals and no correlations with maternal age (p=0.094), maternal weight (p=0.971) or infant age at the time of sample collection (p=0.621). A large number of samples contained low or non-quantifiable concentrations of triclosan and so, in Australia, ubiquitous background exposure due to environmental sources is low. This means that body burden can be influenced by an individual's use of triclosan containing product. Given that triclosan containing product use is continuing, it is important that monitoring in both humans and the environment is continued and that triclosan containing products are adequately labeled so that an individual can choose to avoid exposure.
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http://dx.doi.org/10.1016/j.chemosphere.2011.08.009 | DOI Listing |
J Hazard Mater
January 2025
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610213, China.
The widespread use of antimicrobial agent triclosan (TCS) poses significant health risks to both aquatic organisms and humans. The research on its neurotoxicity and underlying mechanisms is, however, limited. Here we first conducted a 32-day exposure experiment with five TCS concentrations (10, 30, 60, 90 and 120 µg/L) to investigate its impact on overall gene expression in Rana omeimontis larvae.
View Article and Find Full Text PDFMar Pollut Bull
January 2025
College of Environmental Science and Engineering, Dalian Maritime University, Dalian 116026, China. Electronic address:
Triclocarban (TCC) and triclosan (TCS) are applied in a wide range of pharmaceutical and personal care products to prevent or reduce bacterial growth. Due to their extensive application, they are frequently detected in marine environments. In this study, marine sediment systems exposed to different concentrations of TCC and TCS were established to evaluate their effects on microbial communities.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan.
Clay minerals are actively used to obtain a bioactive composite. Kaolinite, as a representative of clay minerals, possesses unique properties essential for the creation of biocomposite materials. This mineral, characterized by its distinctive layered structure, is chemically inert, highly stable, thermally resistant, eco-friendly, biocompatible, and non-toxic.
View Article and Find Full Text PDFMolecules
December 2024
Engineering Laboratory of Chemical Resources Utilization in South Xinjiang, Tarim University, Alar 843300, China.
Hyaluronic acid (HA) is an acidic mucopolysaccharide of animal origin composed of repeating disaccharide units of N-acetylglucosamine and glucuronic acid. Due to its excellent biocompatibility, biodegradability, and selective affinity for CD44 receptors on cell surfaces, HA is widely employed as a drug carrier. In our study, we aimed to target subcellular bacteria by grafting cystamine onto HA scaffolds through an amide reaction, producing a linker responsive to HS and pH changes.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
Institute of Optoelectronics, Military University of Technology, gen. S. Kaliskiego 2, 00-908 Warsaw, Poland.
In order to improve the performance of cement mortar (Portland cement), it was enriched with triclosan, hypochlorous acid, silver nanoparticles and graphene oxide. Cement mortar is used, among other things, to fill the gaps between the tiles of building porcelain stoneware. A number of structural, mechanical and biological tests were carried out.
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