Background: Colorectal cancer is one of the most common cancers in the world, killing nearly 50% of patients afflicted. Though progress is being made within surgery and other complementary treatments, there is still need for new and more effective treatments. Oncolytic virotherapy, meaning that a cancer is cured by viral infection, is a promising field for finding new and improved treatments. We have investigated the oncolytic potential of several low-pathogenic echoviruses with rare clinical occurrence. Echoviruses are members of the enterovirus genus within the family Picornaviridae.
Methods: Six colon cancer cell lines (CaCo-2, HT29, LoVo, SW480, SW620 and T84) were infected by the human enterovirus B species echovirus 12, 15, 17, 26 and 29, and cytopathic effects as well as viral replication efficacy were investigated. Infectivity was also tested in spheroids grown from HT29 cells.
Results: Echovirus 12, 17, 26 and 29 replicated efficiently in almost all cell lines and were considered highly cytolytic. The infectivity of these four viruses was further evaluated in artificial tumors (spheroids), where it was found that echovirus 12, 17 and 26 easily infected the spheroids.
Conclusions: We have found that echovirus 12, 17 and 26 have potential as oncolytic agents against colon cancer, by comparing the cytolytic capacity of five low-pathogenic echoviruses in six colon cancer cell lines and in artificial tumors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213228 | PMC |
| http://dx.doi.org/10.1186/1743-422X-8-473 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synthesis and evaluation of demethylzeylasteral derivatives as potential anticancer therapies for colon cancer: In vitro antiproliferation, cell cycle arrest analyses, network pharmacology investigations, and molecular docking studies.
Fitoterapia
March 2025
College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China; Department of Marine Biopharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China; Marine Biomedical Science and Technology Innovation Platform of Lin-gang Special Area, Shanghai 201306, China. Electronic address:
A series of novel demethylzeylasteral derivatives 1-3 was synthesized by performing modifications on the aldehyde groups at the C-4 positions. Subsequently, the anti - proliferative activities of derivatives 1-3 was evaluated using three human cancer cell line models (HCT116, SKOV3, and HepG2) and the CCK - 8 assay. Compared with demethylzeylasteral, derivative 2 exhibited a remarkable inhibitory effect on HCT116 (4.
View Article and Find Full Text PDF[A Case of Laparoscopic Liver and Colon Resection for Recurrent Hepatocellular Carcinoma and Metachronous Colon Metastasis of Hepatocellular Carcinoma].
Gan To Kagaku Ryoho
February 2025
Dept. of Gastroenterological Surgery, Akita City Hospital.
An 81-year-old man underwent a partial laparoscopic hepatectomy for tumors in the S7 segment of the liver and was diagnosed with moderately to poorly differentiated hepatocellular carcinoma(HCC). Two years and 10 months later, MRI identified a 10 mm tumor in the S8 segment of the liver, indicative of highly differentiated HCC. Colorectal endoscopy subsequently revealed a submucosal tumor in the transverse colon, with biopsy findings showing features similar to the previous HCC.
View Article and Find Full Text PDFMolecular Engineering of a SICTERS Small Molecule with Superior Raman Imaging and Photothermal Performance.
J Am Chem Soc
March 2025
Department of Pharmacology and Chemical Biology, Institute of Molecular Medicine, Collaborative Innovation Center for Clinical and Translational Science by Chinese Ministry of Education & Shanghai, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Raman-based theranostics has demonstrated great potential for sensitive real-time imaging and treatment. However, these advanced materials, primarily depending on the SERS technique, encounter clinical concerns regarding substrate biosafety. Herein, we molecularly engineered a substrate-free SICTERS small molecule, namely BTT-TPA (bis-thienyl-substituted benzotriazole selenadiazole derivative structures), possessing both ultrasensitive Raman signals and excellent photothermal effects based on self-stacking.
View Article and Find Full Text PDFRecent advancements in genistein nanocarrier systems for effective cancer management.
Med Oncol
March 2025
Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, 281406, India.
Cancer continues to be a significant global health concern, consistently ranking as one of the leading causes of mortality across diverse populations and socio-economic contexts. Genistein, a soy-derived isoflavonoid, has gained significant attention for its diverse health benefits, particularly its potent anticancer activity. Emerging pre-clinical and clinical evidences highlights its ability to modulate key cellular processes, including apoptosis, autophagy, angiogenesis, metastasis, immune responses and cell cycle regulation.
View Article and Find Full Text PDFPreparation of capecitabine-poly(p-dioxanone) electrospraying nanoparticles and influence of particle size on their colorectal cancer inhibitive efficiency.
J Biomater Appl
March 2025
Department of Chemistry, School of Pharmacy, North Sichuan Medical College, Nanchong, China.
Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. Capecitabine is a chemotherapeutic agent commonly used for the treatment of colon cancer. To realize local sustained release, promote efficient local intracellular transport, and mitigate the systemic toxic effects of capecitabine, a capecitabine prodrug, capecitabine-poly (p-dioxanone) (Cap-PPDO), was successfully synthesized.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!