AI Article Synopsis
- This case report discusses a rare condition called paraneoplastic pemphigus (PNP), which can cause serious eye issues like cicatrising conjunctivitis.
- Despite initially being misdiagnosed as a drug reaction and not improving after stopping chemotherapy, the patient was later confirmed to have PNP and treated with a combination of oral steroids and intravenous immunoglobulin.
- The patient's eye condition stabilized, leading to a full recovery of vision, highlighting the importance of prompt treatment to prevent serious complications, while noting an unusual eosinophilic response that is more typical of allergic reactions rather than classical PNP.
Article Abstract
We report a case of paraneoplastic pemphigus (PNP) as an uncommon but severe cause of cicatrising conjunctivitis. Initially diagnosed as drug eruptions, the patient's condition did not improve despite cessation of chemotherapy. Immunohistological confirmation of PNP has led to the use of combined oral prednisolone and intravenous immunoglobulin. Her ocular conditions stabilised with complete recovery of vision. PNP is a rare disease that can present with ocular involvement. Ophthalmologists should play an active role in monitoring and treatment of ocular surface complications such as symblepharon formation, severe dry eye and epithelial breakdown. Vigorous and prompt treatment is the key to successful prevention of irreversible and blinding complications. The atypical feature in this case is the presence of eosinophilic infiltration on histology that is a feature of allergic aetiologies rather than classical PNP.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028200 | PMC |
| http://dx.doi.org/10.1136/bcr.12.2008.1306 | DOI Listing |
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