The MYTHEN single-photon-counting (SPC) detector has been characterized using the time-over-threshold (ToT) readout method, i.e. measuring the time that the signal produced by the detected X-rays remains above the comparator threshold. In the following it is shown that the ToT readout preserves the sensitivity, dynamic range and capability of background suppression of the SPC mode, while enhancing the count-rate capability, which is the main limitation of state-of-the-art SPC systems.
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http://dx.doi.org/10.1107/S0909049511034480 | DOI Listing |
EJNMMI Phys
December 2023
Department of Physics of Molecular Imaging Systems, Experimental Molecular Imaging, RWTH Aachen University, Forckenbeckstraße 55, 52074, Aachen, Germany.
Background: Over the past five years, ultrafast high-frequency (HF) readout concepts have advanced the timing performance of silicon photomultipliers (SiPMs). The shown impact in time-of-flight (TOF) techniques can further push the limits in light detection and ranging (LiDAR), time-of-flight positron-emission tomography (TOF-PET), time-of-flight computed tomography (TOF-CT) or high-energy physics (HEP). However, upscaling these electronics to a system-applicable, multi-channel readout, has remained a challenging task, posed by the use of discrete components and a high power consumption.
View Article and Find Full Text PDFCancers (Basel)
November 2023
Department of Nuclear Medicine, Cantonal Hospital Baden, 5404 Baden, Switzerland.
Objective: The increasing use of PSMA-PET/CT for restaging prostate cancer (PCa) leads to a patient shift from a non-metastatic situation based on conventional imaging (CI) to a metastatic situation. Since established therapeutic pathways have been designed according to CI, it is unclear how this should be translated to the PSMA-PET/CT results. This study aimed to investigate whether PSMA-PET/CT and clinical parameters could predict the visibility of PSMA-positive lesions on a bone scan (BS).
View Article and Find Full Text PDFAnal Chem
January 2023
Maastricht MultiModal Molecular Imaging (M4i) Institute, Division of Imaging Mass Spectrometry (IMS), Maastricht University, 6229 ER Maastricht, The Netherlands.
The Timepix (TPX) is a position- and time-sensitive pixelated charge detector that can be coupled with time-of-flight mass spectrometry (TOF MS) in combination with microchannel plates (MCPs) for the spatially and temporally resolved detection of biomolecules. Earlier generation TPX detectors used in previous studies were limited by a moderate time resolution (at best 10 ns) and single-stop detection for each pixel that hampered the detection of ions with high mass-to-charge (/) values at high pixel occupancies. In this study, we have coupled an MCP-phosphor screen-TPX3CAM detection assembly that contains a silicon-coated TPX3 chip to a matrix-assisted laser desorption/ionization (MALDI)-axial TOF MS.
View Article and Find Full Text PDFIEEE Trans Radiat Plasma Med Sci
April 2022
Interdisciplinary Institute for Technological Innovation (3IT) and with the Department of Electrical and Computer Engineering, Université de Sherbrooke, Sherbrooke, QC, Canada J1K 0A5.
The best crystal identification (CI) algorithms proposed so far for phoswich detectors are based on adaptive filtering and pulse shape discrimination (PSD). However, these techniques require free running analog to digital converters, which is no longer possible with the ever increasing pixelization of new detectors. We propose to explore the dual-threshold time-over-threshold (ToT) technique, used to measure events energy and time of occurence, as a more robust solution for crystal identification with broad energy windows in phoswich detectors.
View Article and Find Full Text PDFPhys Med Biol
December 2021
Medical Image and Signal Processing (MEDISIP), Ghent University, Ghent, Belgium.
The vast majority of PET detectors in the field today are based on pixelated scintillators. Yet, the resolution of this type of detector is limited by the pixel size. To overcome this limitation, one can use monolithic detectors.
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