AI Article Synopsis
- There is a link between defects in BMP signaling and the development of gastric tissue tumors like hamartomas and adenomas, but its role in diffuse-type gastric cancer remains unclear.
- The study examined the effects of BMP signaling in three human diffuse-type gastric carcinoma cell lines, revealing that blocking BMP-2/4 receptors promoted faster cell growth.
- Results showed that BMP-4 could halt cell growth by activating the SMAD pathway and p21, while enhancing BMP receptor activity helped reduce cell proliferation, suggesting BMP-2 and BMP-4 may act as significant tumor suppressors in this type of cancer.
Article Abstract
A relationship exists between defects in bone morphogenetic protein (BMP) signaling and formation of hamartoma and adenoma in the gastric epithelium; however, the role of BMP signaling in the progression of diffuse-type gastric carcinoma remains unknown. We investigated whether BMP functions as a tumor suppressor in human diffuse-type gastric carcinoma using three different human diffuse-type gastric carcinoma cell lines (OCUM-12, HSC-39, and OCUM-2MLN). Overexpression of the dominant-negative form of BMP-2/4-specific type I receptor (ALK-3) in OCUM-12 and HSC-39 cells accelerated their growth in vivo. BMP-4 induced cell cycle arrest in these cells via p21 induction through the SMAD pathway. Moreover, overexpression of the constitutively active form of ALK-3 in HSC-39 and OCUM-2MLN cells suppressed the proliferation of these cells in vitro and in vivo. Our findings suggest that BMP-2 and BMP-4 function as potent tumor suppressors in diffuse-type gastric carcinoma.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260801 | PMC |
| http://dx.doi.org/10.1016/j.ajpath.2011.08.022 | DOI Listing |
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