AI Article Synopsis
- The study presents the first complete genomic sequence of human parainfluenza virus 4 (HPIV4), a virus whose genome was previously incomplete.
- The genomic sequence was obtained from a clinical isolate called SKPIV4 at a hospital in Toronto and shows high similarity (95%-97%) with existing partial sequences for HPIV4B.
- HPIV4 has the longest genome in the Rubulavirus genus at over 17 kb, providing valuable new information that will help further research on this respiratory virus.
Article Abstract
Although the human parainfluenza virus 4 (HPIV4) has been known for a long time, its genome, alone among the human paramyxoviruses, has not been completely sequenced to date. In this study we obtained the first complete genomic sequence of HPIV4 from a clinical isolate named SKPIV4 obtained at the Hospital for Sick Children in Toronto (Ontario, Canada). The coding regions for the N, P/V, M, F and HN proteins show very high identities (95% to 97%) with previously available partial sequences for HPIV4B. The sequence for the L protein and the non-coding regions represent new information. A surprising feature of the genome is its length, more than 17 kb, making it the longest genome within the genus Rubulavirus, although the length is well within the known range of 15 kb to 19 kb for the subfamily Paramyxovirinae. The availability of a complete genomic sequence will facilitate investigations on a respiratory virus that is still not completely characterized.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185463 | PMC |
| http://dx.doi.org/10.3390/v1010026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!