Design: Case series.
Setting: Military medical facility providing acute care for soldiers injured while fighting in the war in Iraq and Afghanistan.
Objective: To report a series of infections related to use of continuous peripheral nerve catheters for postoperative pain control in the military polytraumatic setting. The analysis of the above infections includes similarities and differences in infection patterns and attempts to clarify possible risk factors for such infections to include duration of catheter placement, type of catheter, preprocedural antibiotics, and tunnel vs nontunneled catheters. The goal of this analysis is to assist in the development of protocols that may prevent future catheter infections.
Methods: Clinical data were obtained from five previously healthy male soldiers receiving acute care at Brooke Army Medical Center using continuous peripheral nerve catheters for postoperative pain for multiple and frequent procedures.
Results: In a total of six catheter infections, two were noted to have superficial skin infections while four were shown to have deep tissue involvement confirmed by imaging studies. All patients were started on initial or additional antibiotics after catheter removal. Three catheter infections, all with stimulating catheters, required surgical irrigation and debridement in the operating room.
Conclusions: Continuous peripheral nerve catheters are not without complications and risks including infection. Duration of catheter use was the most significant factor with the development of a catheter-related infection in our series. This series also highlights how stimulating and nonstimulating catheter infections may present differently, as stimulating catheters may have a greater tendency to present as deep space infections with minimal superficial findings.
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http://dx.doi.org/10.1111/j.1526-4637.2011.01251.x | DOI Listing |
Ann Transl Med
December 2024
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Background: Osteoarthritis (OA) is increasingly thought to be a multifactorial disease in which sustained gut inflammation serves as a continued source of inflammatory mediators driving degenerative processes at distant sites such as joints. The objective of this study was to use the equine model of naturally occurring obesity associated OA to compare the fecal microbiome in OA and health and correlate those findings to differential gene expression synovial fluid (SF) cells, circulating leukocytes and cytokine levels (plasma, SF) towards improved understanding of the interplay between microbiome and immune transcriptome in OA pathophysiology.
Methods: Feces, peripheral blood mononuclear cells (PBMCs), and SF cells were isolated from healthy skeletally mature horses (n=12; 6 males, 6 females) and those with OA (n=6, 2 females, 4 males).
Clin Auton Res
January 2025
Department of Health and Kinesiology, Purdue University, West Lafayette, Indiana, USA.
Purpose: Resting beat-to-beat blood pressure variability is a strong predictor of cardiovascular events and mortality. However, its underlying mechanisms remain incompletely understood. Given that the sympathetic nervous system plays a pivotal role in cardiovascular regulation, we hypothesized that alpha-1 adrenergic receptors (the main sympathetic receptor controlling peripheral vasoconstriction) may contribute to resting beat-to-beat blood pressure variability.
View Article and Find Full Text PDFSci Prog
January 2025
Department of Trauma and Orthopaedics, NHS Grampian, Aberdeen, UK.
Objective: In this feasibility study, firstly, we aimed to assess whether intramuscular pH (IMpH) could be measured with a glass-tipped electrode. Secondly, we aimed to explore whether we could monitor changes in skeletal muscle pH before and throughout static (isometric) and after dynamic (treadmill) exercise, comparing individuals with intermittent claudication (IC) to a group of healthy controls.
Methods: Forty participants with IC (mean age ± SD) 68 ± 8) and 40 healthy volunteers (63 ± 10) were recruited.
Heliyon
January 2025
Department of Zoology, The University of Burdwan, West Bengal, India.
Thalassemia is a hematological disorder caused by mutations in the hemoglobin gene, often necessitating regular blood transfusions. These frequent transfusions exert continuous pressure on patients' immune systems. Despite extensive research on the hematological aspects of thalassemia, few studies have explored the immune status of these patients.
View Article and Find Full Text PDFeNeuro
January 2025
Action Control Lab, Department of Human Physiology, University of Oregon, Eugene, Oregon, USA.
Selectively stopping individual parts of planned or ongoing movements is an everyday motor skill. For example, while walking in public you may stop yourself from waving at a stranger who you mistook for a friend while continuing to walk. Despite its ubiquity, our ability to selectively stop actions is limited.
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