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International consensus to define outcomes for trials of chemoradiotherapy for anal cancer (CORMAC-2): defining the outcomes from the CORMAC core outcome set.
EClinicalMedicine
December 2024
NIHR Manchester Biomedical Research Centre, Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester, UK.
Variation in outcomes definitions and reporting limit the utility of clinical trial results. The Core Outcome Research Measures in Anal Cancer (CORMAC) project developed a core outcome set (COS) for chemoradiotherapy trials for anal squamous cell carcinoma (ASCC) through an international healthcare professional and patient consensus process. The CORMAC-COS comprises 19 outcomes across 4 domains (disease activity, survival, toxicity, life impact).
View Article and Find Full Text PDFHeat-related mortality in Mexico: A multi-scale spatial analysis of extreme heat effects and municipality-level vulnerability.
Environ Int
December 2024
Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA; Irset Institut de Recherche en Santé, Environnement et Travail, UMR-S 1085, Inserm, University of Rennes, EHESP, Rennes, France.
Understanding effects of extreme heat across diverse settings is critical as social determinants play an important role in modifying heat-related risks. We apply a multi-scale analysis to understand spatial variation in the effects of heat across Mexico and explore factors that are explaining heterogeneity. Daily all-cause mortality was collected from the Mexican Secretary of Health and municipality-specific extreme heat events were estimated using population-weighted temperatures from 1998 to 2019 using Daymet and WorldPop datasets.
View Article and Find Full Text PDFNovel versions of Hölder's-Like and related inequalities with newly defined space, and their applications over fuzzy domain.
Heliyon
December 2024
Department of Mathematics, Faculty of Science, Jazan University, Jazan, 45142, Saudi Arabia.
It is widely recognized that fuzzy number theory relies on the characteristic function. However, within the fuzzy realm, the characteristic function transforms into a membership function contingent upon the interval [0,1]. This implies that real numbers and intervals represent exceptional cases of fuzzy numbers.
View Article and Find Full Text PDFThe dynamics of prion spreading is governed by the interplay between the non-linearities of tissue response and replication kinetics.
iScience
December 2024
Université Paris-Saclay, INRAe, UVSQ, VIM, 78350 Jouy-en-Josas, France.
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are neurodegenerative disorders caused by the accumulation of misfolded conformers (PrP) of the cellular prion protein (PrP). During the pathogenesis, the PrP seeds disseminate in the central nervous system and convert PrP leading to the formation of insoluble assemblies. As for conventional infectious diseases, variations in the clinical manifestation define a specific prion strain which correspond to different PrP structures.
View Article and Find Full Text PDFInequalities in the Quality and Safety of Post-Diagnostic Primary Care for People With Dementia: A Scoping Review.
Int J Geriatr Psychiatry
December 2024
Population Health Science Institute, Faculty of Medical Science, Newcastle University, Newcastle-upon-Tyne, UK.
Introduction: International guidelines make recommendations for the delivery of safe, high-quality primary care for people with dementia including prescribing, personalised care planning and regular holistic reviews. It is unclear how the quality and safety of this healthcare varies with socio-economic factors.
Objective: This scoping review aimed to understand the depth and breadth of existing evidence exploring socio-economic variation in the quality and safety of primary care for people with dementia.
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