Objectives: Acacia catechu heartwood contains significant amounts of polyphenolic compounds that exhibit powerful antioxidant activity. The purpose of this study was to evaluate the cytotoxicity of A. catechu heartwood extracts in a human epithelial carcinoma cell line (A431) and antitumour activity against DMBA/TPA induced squamous cell carcinoma in Balb/c mice.
Methods: Various extracts, including aqueous, ethyl acetate, chloroform and n-hexane, were tested for cytotoxic properties on a human epithelial carcinoma cell line (A431) by using MTT, sulforhodamine B and lactate dehydrogenase leakage assays. The standardized A. catechu heartwood aqueous extract (AQCE) was further evaluated for antitumour activity against 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) induced skin carcinoma in Balb/c mice.
Key Findings: The results showed that administration of AQCE showed a dose-dependent growth inhibition response, with an IC50 value of 78.56 µg/ml. Tumour incidence was significantly decreased (P < 0.001) to 30% with AQCE compared with 100% in the DMBA/TPA group. The AQCE was also found to significantly upregulate different antioxidant enzymes in skin and liver tissue.
Conclusions: The results suggest that AQCE may exert its chemopreventive activity by acting as an antioxidant.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.2042-7158.2011.01354.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Optimization of betulinic and ursolic acids and phenolics extraction from endemic Rosa pisiformis using Box-Behnken design in relation to cytotoxic activities.
Sci Rep
January 2025
Section of Botany, Department of Biology, Science Faculty, Ege University, Bornova, İzmir, Turkey.
Despite its important pharmacological bioactivities, betulinic acid is still primarily obtained through extraction from heartwood and bark or synthesized synthetically, with less than 3% efficiency. Our endemic rose species, Rosa pisiformis (Christ.) D.
View Article and Find Full Text PDFEffects of and extract on cognitive function in a healthy adult population: a double-blind, randomized, placebo-controlled trial.
Nutr Neurosci
December 2024
Exercise and Performance Nutrition Laboratory, College of Science, Technology and Health, Lindenwood University, St. Charles, MO, USA.
Unlabelled: Flavonoids, known for their neuroprotective properties, are abundant in and Yet, human studies on their combined effects are limited.
Objective: This study evaluated the cognitive effects of combined and supplementation in healthy adults.
Methods: In a randomized, double-blind, placebo-controlled trial, 26 males and 59 females ( = 85; 43 ± 8 yrs) consumed the test product (TP) containing 240 mg stem extract of and 51 mg heartwood extract of (UP326, Unigen, Tacoma, WA USA) or placebo (PLA) for four weeks.
Botanical Bioflavonoid Composition from - and -Protected Mice against D-Galactose-Induced Immunosenescence, and Cyclophosphamide Induced Immune Suppression.
Nutrients
September 2024
Unigen Inc., 2121 South State Street, Suite #400, Tacoma, WA 98405, USA.
Oxidative stress and chronic inflammation create a perpetual cycle in the elderly, where impaired immune function amplifies susceptibility to oxidative damage, and oxidative stress further weakens the immune response. This cycle is particularly detrimental to the respiratory system of the elderly, which is an easy target for constant exogenous harmful attacks during cold/flu season or under heavy air pollution. Herbal medicines that protect respiratory function are seen as safer alternatives to conventional therapies; however, there is limited availability of scientifically validated, safe, and effective natural supplements for these conditions.
View Article and Find Full Text PDFWilld. Extract Protects Neuronal Cells from Oxidative Stress-Induced Damage.
Antioxidants (Basel)
December 2021
Dipartimento di Scienze della Vita, Università di Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Oxidative stress (OS) and the resulting reactive oxygen species (ROS) generation and inflammation play a pivotal role in the neuronal loss occurring during the onset of neurodegenerative diseases. Therefore, promising future drugs that would prevent or slow down the progression of neurodegeneration should possess potent radical-scavenging activity. Willd.
View Article and Find Full Text PDFAnti-inflammatory properties of ethanolic extract from Vatairea macrocarpa leaves.
J Ethnopharmacol
October 2021
Federal University of Grande Dourados, Faculty of Health Sciences, Dourados, MS, Brazil. Electronic address:
Ethnopharmacological Relevance: In Brazilian traditional folk medicine, the leaves and heartwood from Vatairea macrocarpa (Benth) Ducke (Angelim-of-Cerrado) (Fabaceae family) are used as remedy after cold maceration for the treatment of the condition popularly known as rheumatism, as well as for the general inflammatory aspects such as pains, injury and swelling. The rheumatological and rheumatic diseases affect 0.3-1.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!