Simplified synthesis of isotopically labeled 5,5-dimethyl-pyrroline N-oxide.

Molecules

Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA.

Published: October 2011

5,5-Dimethylpyrroline N-oxide (15N) and 5,5-di(trideuteromethyl)pyrroline N-oxide were synthesized from the respective isotopically labeled 2-nitropropane analogs obtained from the reaction of sodium nitrate with 2-halopropanes. This facile, straightforward process allows synthesizing isotopically labeled DMPO analogs in a 4-step reaction without special equipment.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258118PMC
http://dx.doi.org/10.3390/molecules16108428DOI Listing

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