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Retrospective observational study of safety, performance, and duration of use of battery-powered intraosseous access device in pediatric patients.
SAGE Open Med
December 2024
Teleflex Incorporated, Morrisville, NC, USA.
Background: To demonstrate the safety and performance of the Arrow EZ-IO Intraosseous Vascular Access System, particularly in the pediatric patient population, a retrospective observational study was conducted in 2021 and 2022.
Methods: Following study design, IRB approval, and investigator selection, data were collected for all patients needing intraosseous access-adult and pediatric. The primary endpoint was the success rate for achieving intraosseous access; the secondary endpoint was the rate of adverse events.
Safety, efficacy, and reliability evaluation ofa novel small-diameter defibrillation lead: Global LEADR pivotal trial results.
Heart Rhythm
October 2024
University of Virginia Medical Center, Charlottesville, Virginia. Electronic address:
Article Synopsis
- The OmniaSecure defibrillation lead is a new, small-diameter lead aimed at improving targeted placement for better long-term performance in implantable cardioverter-defibrillators.
- The LEADR pivotal clinical trial involved 643 patients and showed that the lead was successfully placed in the correct position for 99.5% of participants, with a 97.5% success rate for defibrillation at implantation.
- The trial results indicated high safety and efficacy, with a 97.1% freedom from major complications and no lead fractures over an average follow-up of 12.7 months.
First-line nivolumab plus ipilimumab with or without chemotherapy for Japanese patients with non-small cell lung cancer: LIGHT-NING study.
Jpn J Clin Oncol
April 2024
Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.
Article Synopsis
- The study assesses combination immunotherapy with nivolumab and ipilimumab for stage IV or recurrent non-small cell lung cancer in Japanese patients, revealing potential survival benefits compared to chemotherapy.
- In an analysis of 353 patients over an average follow-up of 7.1 months, safety was monitored with 32.1% of those treated experiencing serious adverse events, mainly in the first month.
- The results indicate a median progression-free survival of approximately 6.0 months for patients receiving immunotherapy with chemotherapy and 5.8 months without, providing important clinical insights for similar patient populations.
Supporting self-determination among internationally educated nurses: a discussion.
Contemp Nurse
December 2023
School of Nursing, Duke University, 307 Trent Drive, DUMC 3322, Durham, NC 27710, USA.
: The COVID-19 pandemic has exacerbated the global nursing shortage. As the shortage worsens, reliance on internationally educated nurses is expected to increase, presenting challenges and opportunities for health care systems and nurse leaders worldwide. While internationally educated nurses bring cultural and ethnic diversity to domestic workforces, they face significant hurdles in successfully integrating due to racism, discrimination, and isolation, which can have a negative impact on their self-determination.
View Article and Find Full Text PDFA randomised pilot feasibility study of eye movement desensitisation and reprocessing recent traumatic episode protocol, to improve psychological recovery following intensive care admission for COVID-19.
J Intensive Care Soc
August 2023
NIHR Southampton Biomedical Research Centre, University Hospitals Southampton National Health Service Foundation Trust, Southampton, UK.
Background: Approximately 50% of intensive care survivors experience persistent psychological symptoms. Eye-movement desensitisation and reprocessing (EMDR) is a widely recommended trauma-focussed psychological therapy, which has not been investigated systematically in a cohort of intensive care survivors: We therefore conducted a randomised pilot feasibility study of EMDR, using the Recent Traumatic Episode Protocol (R-TEP), to prevent psychological distress in intensive care survivors. Findings will determine whether it would be possible to conduct a fully-powered clinical effectiveness trial and inform trial design.
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