Three new hydroquinone terpenoids with benzogeijerene skeletons, euchroquinols A-C (1- 3), and a new monoterpenylbenzenoid, 9,17-epoxyarnebinol (4), along with five known compounds were isolated from the stem bark of ARNEBIA EUCHROMA. Shikonin (6) exhibited potent anti-HCV activity with a selective index of 43.56, and compounds 1, 6, and des-O-methyllasiodiplodin (7) showed anti-Staphylococcus aureus activity with MICs of 0.5, 0.125, and 0.125 mg/mL, respectively.
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http://dx.doi.org/10.1055/s-0031-1280266 | DOI Listing |
Pharmaceutics
December 2024
College of Pharmacy, Xinjiang Second Medical College, Karamay 834000, China.
, an active component of Arnebia euchroma (Royle) Johnst., has remarkable pharmacological effects, particularly in its anti-tumour activity. Nonetheless, the specific targets and mechanisms of action remain to be further explored.
View Article and Find Full Text PDFPhytother Res
January 2025
College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
The rising prevalence of multidrug-resistant (MDR) Gram-positive bacteria threatens the effectiveness of current antibiotic therapies. However, the development of new antibiotics has stagnated in recent years, highlighted the critical need for the discovery of innovative antimicrobial agents. This study aims to evaluate the antibacterial activity of naphthoquinones derived from Arnebia euchroma (Royle) Johnst (ADNs) and elucidate their underlying mechanisms.
View Article and Find Full Text PDFPhytomedicine
January 2025
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China; Key Laboratory of Biology and Cultivation of Herb Medicine, Ministry of Agriculture and Rural Affairs, Beijing, 100700, PR China. Electronic address:
Background: Arnebiae Radix has long been used in traditional medicine for its pleiotropic properties. However, distinguishing Arnebiae Radix from its substitutes or closely related species has been challenging due to limited phenotypic characteristics.
Purpose: We aimed to identify the molecular markers for distinguishing Arnebiae Radix from its confusion species.
J Org Chem
January 2025
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutica Sciences, Peking University, Beijing 100191, China.
Arnebidin, a heptacyclic naphthoquinone dimer with a tricyclo[3.3.0.
View Article and Find Full Text PDFPhytochemistry
April 2025
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutica Sciences, Peking University, Beijing, 100191, China. Electronic address:
Twenty-one anthraquinones were discovered from the petroleum ether soluble fraction of the crude ethanol extract of Arnebia euchroma (Royle) I. M. Johnst.
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