Attention is drawn to the increase of the pressure on the skin due to the introduction of a measuring probe under an elastic garment. The increase of pressure is explained by looking at the force equilibrium on the transducer. Making some assumptions on the geometry and the conditions that actually prevail at the interface, this mechanical phenomenon is expressed mathematically. Expressions for estimating the order of magnitude of the relative pressure perturbation are derived both for the case of a cylindrical probe and for a thin plate probe with the same curvature as the limb. Thanks to the geometrical assumptions, these expressions are independent of the mechanical properties of the probe and the soft tissue. As in some of these formulas the magnitude of the indentation appears, a measurement is necessary for estimating the error. Other expressions, only taking in account the dimensions of the limb and the probe, give a rougher estimation of the error. It is shown through a few practical examples that the error cannot be disregarded and cannot be calculated precisely, which means that this measuring technique is unreliable. The same mathematical expressions are used to show that pressure paddings effectively increase the pressure. It is also shown that the introduction of an optical fibre under the garment, used in laser Doppler flowmetry, creates an important additional pressure on the skin.
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Ecotoxicol Environ Saf
January 2025
Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental Pollution, School of Life Sciences, Lanzhou University, Lanzhou 730000, China. Electronic address:
Habitat fragmentation represents a multifaceted global conservation threat, exerting both direct and indirect effects on individual animals and communities. Reptiles, particularly smaller species with limited migratory abilities, are especially vulnerable to these changes. This study examines how small reptiles adapt their life history strategies in fragmented habitats and determines whether their responses are primarily due to phenotypic plasticity or genetic adaptation.
View Article and Find Full Text PDFPLoS One
January 2025
Water Resources Engineering Department, College of Engineering, Salahaddin University, Erbil, Iraq.
This paper addresses the mechanical characteristics of a passive earth pressure problem taking into account water retention curve (SWRC) hysteresis. Both hydraulic (drying and wetting cycles) and mechanical hysteresis were considered. Parametric studies were carried out at various air entry values (AEV = 5-30 kPa), different wall frictions (δ = 0, 0.
View Article and Find Full Text PDFSci Adv
January 2025
Department of Neuroscience, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Homeostatic sleep regulation is essential for optimizing the amount and timing of sleep for its revitalizing function, but the mechanism underlying sleep homeostasis remains poorly understood. Here, we show that optogenetic activation of locus coeruleus (LC) noradrenergic neurons immediately increased sleep propensity following a transient wakefulness, contrasting with many other arousal-promoting neurons whose activation induces sustained wakefulness. Fiber photometry showed that repeated optogenetic or sensory stimulation caused a rapid reduction of calcium activity in LC neurons and steep declines in noradrenaline/norepinephrine (NE) release in both the LC and medial prefrontal cortex (mPFC).
View Article and Find Full Text PDFAlzheimers Dement
January 2025
Department of Neurology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, P. R. China.
Introduction: To examine the longitudinal association between estimated pulse wave velocity (ePWV) and cognitive phenotypes in a rural Chinese older population.
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J Clin Hypertens (Greenwich)
January 2025
Division of Public Health, Hygiene and Epidemiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan.
In this study, we aimed to reveal the trends of self-measured blood pressure (SMBP) and SMBP-derived indices during pregnancy and the postpartum period. The Babies and Their Parents Longitudinal Observation in Suzuki Memorial Hospital in the Intrauterine Period (BOSHI) Study is a prospective cohort study in Japan. Participants were instructed to measure SMBP daily during pregnancy and for 1 month after delivery.
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