Based on the anti-hepatitis C activity of 2'-C-methyl-adenosine and 2'-C-methyl-guanosine, a series of new modified purine 2'-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2'-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352596 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2011.09.034 | DOI Listing |
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