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Endothelial-specific knockout of the scramblase TMEM16F impairs in vivo clot formation.
Shock
January 2025
Pharmacology, University of Vermont, Burlington, VT.
Objective: Loss of function of the phospholipid scramblase (PLS) TMEM16F results in Scott Syndrome, a hereditary bleeding disorder generally attributed to intrinsic platelet dysfunction. The role of TMEM16F in endothelial cells, however, is not well understood. We sought to test the hypothesis that endothelial TMEM16F contributes to hemostasis by measuring bleeding time and venous clotting in endothelial-specific knockout (ECKO) mice.
View Article and Find Full Text PDFThe impact of external perturbations on postural control.
Acta Bioeng Biomech
June 2024
1Faculty of Rehabilitation, Józef Piłsudski University of Physical Education in Warsaw, Warsaw, Poland.
: External factors can disrupt postural control, but the intricate workings of the postural control system enable an appropriate response. This study seeks to assess how external perturbations affect postural control. : Twenty women participated in study, which consisted four trials involved quiet standing and experiencing induced perturbations by being struck with a boxing bag from the back, right, and left sides, respectively.
View Article and Find Full Text PDFImpact of exercise with blood flow restriction on muscle hypertrophy and performance outcomes in men and women.
PLoS One
January 2025
Cardiometabolic, Exercise, and Lifestyle Laboratory, University of New Brunswick, Fredericton, NB, Canada.
Blood flow restriction training (BFRT) has been previously studied as an alternative form of resistance training to gain lean mass and improve performance outcomes. However, in all exercise studies of BFRT, the proportion of female participants represents only 17-29% of all research participants. This highlights a strong underrepresentation of females and the need for more knowledge on the impact of BFRT and sex differences.
View Article and Find Full Text PDFCognitive Impairment in Primary Open Angle Glaucoma: A Case Control Study.
J Glaucoma
January 2025
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Prcis: Cognitive impairment in multiple domains was observed in primary open angle glaucoma patients as compared to age and gender matched healthy controls.
Objective: Evaluation of cognitive impairment in individuals with Primary Open Angle Glaucoma (POAG).
Methods: In this case-control study, individuals with POAG (cases, n=70) were compared with age- and sex-matched healthy individuals (controls, n=70) using detailed ophthalmological evaluation, cognitive assessment and serum cortisol level.
One-Year Real-World Outcomes of Ab-Externo Gel Stent Placement From the EXPAND Study.
J Glaucoma
January 2025
Wills Eye Hospital Glaucoma Service, Philadelphia, PA, USA.
Prcis: In the real-world, retrospective, EXPAND study of consecutive adults with glaucoma, ab-externo gel stent implantation effectively lowered intraocular pressure (34%) and the medication burden (61%), with transient/self-resolving hypotony as the most frequent adverse event (28%).
Purpose: To assess effectiveness and safety of ab-externo gel stent (GS) implantation in glaucoma.
Methods: Multicenter, real-world, retrospective study.
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