Multiscale stochastic modelling of gene expression.

J Math Biol

Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, UK.

Published: September 2012

Stochastic phenomena in gene regulatory networks can be modelled by the chemical master equation for gene products such as mRNA and proteins. If some of these elements are present in significantly higher amounts than the rest, or if some of the reactions between these elements are substantially faster than others, it is often possible to reduce the master equation to a simpler problem using asymptotic methods. We present examples of such a procedure and analyse the relationship between the reduced models and the original.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00285-011-0468-7DOI Listing

Publication Analysis

Top Keywords

master equation
8
multiscale stochastic
4
stochastic modelling
4
modelling gene
4
gene expression
4
expression stochastic
4
stochastic phenomena
4
phenomena gene
4
gene regulatory
4
regulatory networks
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!