AI Article Synopsis
- 2-Hydroxypyridine (2-HPY) is generated from the breakdown of 2-halogenated pyridines and poses genotoxic risks when dissolved in water.
- The genotoxicity was assessed using UV irradiation at 254 nm, with concentration and total organic carbon levels measured over time.
- Results showed that 2-HPY was genotoxic across various concentrations, but prolonged UV exposure significantly lowered its genotoxic effects close to control levels.
Article Abstract
2-Hydroxypyridine (2-HPY) is a major first-stage product formed upon the photolytic destruction of 2-halogenated pyridines. Genotoxicity of 2-HPY in water was studied as a function of concentration. Aqueous solutions of 2-HPY were irradiated by ultraviolet (UV) at 254 nm. 2-HPY concentration, solution total organic carbon (TOC) concentration and solution genotoxicity were measured as a function of treatment time and their profile as a function of time is presented in this work. 2-HPY was found to be genotoxic at all concentrations in the range of 5-400 μg ml(-1). 2-HPY mineralises completely upon prolonged UV irradiation. All untreated and irradiated solution samples, taken at different photo-treatment times, were tested in cultured human lymphocytes applying the cytokinesis block micronucleus (CBMN) assay. The genotoxicity of the solution was reduced near to the control level after prolonged UV irradiation.
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| http://dx.doi.org/10.1016/j.jhazmat.2011.09.065 | DOI Listing |
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