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Artificial intelligence and machine learning in cell-free-DNA-based diagnostics.
Genome Res
January 2025
Center for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong SAR, China;
The discovery of circulating fetal and tumor cell-free DNA (cfDNA) molecules in plasma has opened up tremendous opportunities in noninvasive diagnostics such as the detection of fetal chromosomal aneuploidies and cancers and in posttransplantation monitoring. The advent of high-throughput sequencing technologies makes it possible to scrutinize the characteristics of cfDNA molecules, opening up the fields of cfDNA genetics, epigenetics, transcriptomics, and fragmentomics, providing a plethora of biomarkers. Machine learning (ML) and/or artificial intelligence (AI) technologies that are known for their ability to integrate high-dimensional features have recently been applied to the field of liquid biopsy.
View Article and Find Full Text PDFCarbon Cycle of Polyhydroxyalkanoates (CCP): Biosynthesis and Biodegradation.
Environ Res
January 2025
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Department of Life Sciences and Medicine, Northwest University, Xi'an, 710069, China; School of Clinical Medicine, Chengdu University, Chengdu, China; Shaanxi Key Laboratory for Carbon Neutral Technology, Xi'an, 710069, China. Electronic address:
Carbon neutrality of bioactive materials is vital in promoting sustainable development for human society. Polyhydroxyalkanoates (PHAs) is a class of typical carbon-cycle bio-polyesters synthesized by microorganisms using sugars, organic acids, and even carbon dioxide. PHAs first degrade into 3-hydroxybutyrate (3HB) before further breaking down into carbon dioxide and water, aligning with carbon-neutral goals.
View Article and Find Full Text PDFCircadian gating: concepts, processes, and opportunities.
Philos Trans R Soc Lond B Biol Sci
January 2025
John Innes Centre, Norwich Research Park, Norwich, UK.
Circadian clocks provide a biological measure of time that coordinates metabolism, physiology and behaviour with 24 h cycles in the environment. Circadian systems have a variety of characteristic properties, such as entrainment to environmental cues, a self-sustaining rhythm of about 24 h and temperature compensation of the circadian rhythm. In this perspective, we discuss the process of circadian gating, which refers to the restriction of a biological event to particular times of day by the circadian clock.
View Article and Find Full Text PDFVentricular-Arterial Coupling: Changes with aging and implications across cardiovascular conditions.
Blood Press
January 2025
Jagiellonian University Medical College, 1st Department of Cardiology, Interventional Electrocardiology and Arterial Hypertension, Kraków, Poland.
Purpose: Ventricular-arterial coupling (VAC) is a crucial concept in cardiovascular physiology, representing the dynamic interaction between the left ventricle and the arterial system. This comprehensive literature review explores the changes in VAC with aging and various cardiovascular diseases (CVDs).
Materials And Methods: This literature review covers studies on changes in VAC with age and common CVDs such as arterial hypertension, atrial fibrillation, heart failure with preserved and reduced ejection fraction and aortic stenosis.
Semi-Confinement Effect Enhances CH and CH Production in CO Electrocatalytic Reduction.
Small
January 2025
Key Laboratory of Marine Chemistry Theory and Technology (Ministry of Education), College of Chemistry & Chemical Engineering, Ocean University of China, 238 Songling Road, Qingdao, 266100, China.
Achieving fast conversion and precise regulation of product selectivity in electrochemical CO reduction reaction (CORR) remains a challenge. The space confinement effect provides a theoretical basis for the design of catalysts of different morphology and sizes and reveals the physical phenomena caused by the confinement of electrons and other particles at the nanoscale. In this work, a semi-confinement concept is introduced and a mesoporous silica nanosphere supported Cu catalyst (Cu-MSN) is prepared as a typical example to realize CORR enhancement and product selectivity regulation (methane vs ethylene).
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