A 46-year-old man was referred to our hospital for treatment, complaining of swelling on the right mandibular molar region. Radiographic examination revealed a well defined multilocular radiolucent lesion with root resorption of right lower anteriors and molars. Following biopsy, a diagnosis of unicystic ameloblastoma of mural type was made and hemimandibulectomy was performed under general anesthesia. Histopathological examination of the surgical specimen exhibited a unicystic ameloblastoma of luminal, intraluminal, and mural type. Intraluminal proliferation was of plexiform pattern and mural proliferation showed unusual histopathological findings, which revealed follicular, acanthomatous areas coexisted with desmoplastic areas. This mural picture was similar to the so-called 'hybrid lesion of ameloblastoma', whose biological profile is not elicited due to the lack of adequate published reports. Two years follow up till date has not revealed any signs of recurrence.
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http://dx.doi.org/10.5624/isd.2011.41.1.29 | DOI Listing |
Semin Diagn Pathol
January 2025
Dept of Oral & Maxillofacial Pathology and Oral Microbiology, King George's Medical University, Lucknow, India. Electronic address:
Ameloblastomas (AM) are locally aggressive tumors, with hemangiomatous ameloblastoma (HA) being a rare subtype characterized by vascular proliferation, predominantly in the stroma but occasionally within the epithelial component. We report a case of a 32-year-old male with recurrent mandibular swelling, histopathologically diagnosed as unicystic HA, showing vascularity in both stroma and odontogenic epithelial islands with GLUT1 positivity in the latter. A review of 31 cases revealed a male predilection, mandibular dominance (89.
View Article and Find Full Text PDFSemin Diagn Pathol
January 2025
King George's Medical University Faculty of Dental Sciences, India. Electronic address:
Ameloblastoma is a benign odontogenic epithelial tumor characterized by its aggressive behavior and a high likelihood of local recurrence if not fully excised. Ameloblastomas are a common type of slow-growing, true jaw tumor which may present as solid, multicystic or unicystic forms and originate from odontogenic epithelium and exhibit a variety of histological patterns. Keratoameloblastoma is considered to be a rare variant of ameloblastoma associated with more intense keratinization.
View Article and Find Full Text PDFJ Clin Exp Dent
December 2024
Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirot University.
Background: N6-methyladenosine (m6A), the most abundant internal RNA modification in mammals, plays a critical role in many forms of cancer. Methyltransferase-like 3 (METTL3) serves as the main catalytic subunit of the m6A writer and plays a role in the progression of head and neck squamous cell carcinoma. To date, the role of METTL3 in odontogenic lesions has never been investigated.
View Article and Find Full Text PDFHead Neck Pathol
December 2024
Institute of Pathology, Sheba Medical Center, Tel Hashomer, 5265601, Israel.
Purpose: Current standard of care for ameloblastoma (conventional/unicystic - mural type) usually mandates extensive bone resection that frequently necessitates immediate reconstruction with serious sequelae, especially among young patients. BRAF-mutated ameloblastomas can be targeted by BRAF inhibitors to markedly reduce their size, enabling conservative removal of residual tumor. We aimed to characterize the effect of post-treatment histomorphologic changes.
View Article and Find Full Text PDFAppl Immunohistochem Mol Morphol
November 2024
Department of Basic Sciences, College of Dentistry, Princess Nourah bint Abdulrahman University, 84428, Riyadh 11671, Saudi Arabia.
Odontogenic cysts and tumors exhibit a broad spectrum of biological characteristics. Despite recent advances in understanding the complex nature of these lesions, relatively less is known about the molecular markers involved in key pathogenic steps, such as proliferation and differentiation. This study aimed to elucidate the expression patterns of p63 and Ki-67 in odontogenic lesions, which may influence the management strategies.
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