AI Article Synopsis
- The study assessed the effectiveness of the LAMP method for diagnosing malaria using specific primers for human malaria parasites in a field clinic in Thailand.
- LAMP demonstrated high sensitivity (98.3%) by correctly identifying 59 out of 60 samples that were positive by standard microscopy, while achieving 100% specificity by identifying none of the 50 samples that were negative.
- The test showed a negative predictive value (NPV) of 98% and a positive predictive value (PPV) of 100%, confirming LAMP as a reliable tool for malaria diagnosis in field settings.
Article Abstract
We used the loop-mediated isothermal amplification (LAMP) method developed by our group for malaria diagnosis with genus-specific and species-specific primers for the four human malaria parasites at a field clinic in comparison with standard microscopy. Among 110 blood samples collected from the malaria clinic in Thailand, LAMP detected 59 of 60 samples positive by microscopy (sensitivity = 98.3%) and none of the 50 microscopy-negative samples (specificity = 100%). Negative predictive value (NPV) and positive predictive value (PPV) of LAMP were 98% and 100%, respectively. These results indicate that LAMP is an effective tool for malaria diagnosis at a field clinic in a field setting.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183761 | PMC |
| http://dx.doi.org/10.4269/ajtmh.2011.10-0676 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!