AI Article Synopsis
Article Abstract
New N-acylhomoserine lactone (AHL) analogues in which the amide function is replaced by a reverse-amide one have been studied as AHL QS modulators. The series of compounds consists of α-(N-alkyl-carboxamide)-γ-butyrolactones, α-(N-alkyl-sulfonamide)-γ-butyrolactones, and 2-(N-alkyl-carboxamide)-cyclopentanones and cyclopentanols. Most active compounds exhibited antagonist activities against LuxR reaching the 30 μM range.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2011.09.010 | DOI Listing |
Publication Analysis
Top Keywords
α-n-alkyl-carboxamide-γ-butyrolactones α-n-alkyl-sulfonamide-γ-butyrolactones
8
ahl-dependent quorum
4
quorum sensing
4
sensing inhibition
4
inhibition synthesis
4
synthesis biological
4
biological evaluation
4
evaluation α-n-alkyl-carboxamide-γ-butyrolactones
4
α-n-alkyl-sulfonamide-γ-butyrolactones n-acylhomoserine
4
n-acylhomoserine lactone
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!