Many studies yield multivariate multiblock data, that is, multiple data blocks that all involve the same set of variables (e.g., the scores of different groups of subjects on the same set of variables). The question then rises whether the same processes underlie the different data blocks. To explore the structure of such multivariate multiblock data, component analysis can be very useful. Specifically, 2 approaches are often applied: principal component analysis (PCA) on each data block separately and different variants of simultaneous component analysis (SCA) on all data blocks simultaneously. The PCA approach yields a different loading matrix for each data block and is thus not useful for discovering structural similarities. The SCA approach may fail to yield insight into structural differences, since the obtained loading matrix is identical for all data blocks. We introduce a new generic modeling strategy, called clusterwise SCA, that comprises the separate PCA approach and SCA as special cases. The key idea behind clusterwise SCA is that the data blocks form a few clusters, where data blocks that belong to the same cluster are modeled with SCA and thus have the same structure, and different clusters have different underlying structures. In this article, we use the SCA variant that imposes equal average cross-products constraints (ECP). An algorithm for fitting clusterwise SCA-ECP solutions is proposed and evaluated in a simulation study. Finally, the usefulness of clusterwise SCA is illustrated by empirical examples from eating disorder research and social psychology.
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Acad Med
December 2024
R.H. Kon is associate professor of medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Virginia; ORCID: https://orcid.org/0000-0002-3326-5203.
ProblemLongitudinal patient relationships can positively affect medical students' professional identity formation (PIF), understanding of illness, and socialization within medical practice, but a longitudinal integrated clerkship (LIC) model is not always feasible. The authors describe the novel Patient Student Partnership (PSP) program, which provides authentic roles for students in mentored longitudinal patient relationships while maintaining a traditional block clerkship model.ApproachThe PSP program at the University of Virginia School of Medicine pairs all matriculating medical students with a patient living with chronic illness to follow across multiple health care settings until graduation.
View Article and Find Full Text PDFPLoS One
January 2025
School of Mathematics and Statistics, Nanjing University of Information Science and Technology, Nanjing, Jiangsu, China.
Optical Coherence Tomography (OCT) offers high-resolution images of the eye's fundus. This enables thorough analysis of retinal health by doctors, providing a solid basis for diagnosis and treatment. With the development of deep learning, deep learning-based methods are becoming more popular for fundus OCT image segmentation.
View Article and Find Full Text PDFJ Vis
January 2025
Department of Psychology, New York University, New York, NY, USA.
Active object recognition, fundamental to tasks like reading and driving, relies on the ability to make time-sensitive decisions. People exhibit a flexible tradeoff between speed and accuracy, a crucial human skill. However, current computational models struggle to incorporate time.
View Article and Find Full Text PDFHeart Vessels
January 2025
Department of Cardiology, Fujian Medical University Union Hospital, Fujian Institute of Coronary Heart Disease, Fujian Heart Medical Center, Fuzhou, 350001, Fujian, China.
Left bundle branch pacing (LBBP) is an emerging physiological pacing technique characterized by stable pacing parameters and a narrower QRS duration. This study aims to compare the long-term efficacy and safety of biventricular pacing (BIVP) and LBBP in patients with heart failure with reduced ejection fraction (HFrEF) and complete left bundle branch block (CLBBB). A retrospective analysis was conducted on 35 patients with chronic HFrEF accompanied by CLBBB treated at our center from April 2018 to October 2022.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Chambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, School of Integrated Health Sciences, University of Nevada Las Vegas, Las Vegas, NV, USA.
Background: Although high-throughput DNA/RNA sequencing technologies have generated massive genetic and genomic data in human disease, translation of these findings into new patient treatment has not materialized by lack of effective approaches, such as Artificial Intelligence (AL) and Machine Learning (ML) tools.
Method: To address this problem, we have used AI/ML approaches, Mendelian randomization (MR), and large patient's genetic and functional genomic data to evaluate druggable targets using Alzheimer's disease (AD) as a prototypical example. We utilized the genomic instruments from 9 expression quantitative trait loci (eQTL) and 3 protein quantitative trait loci (pQTL) datasets across five human brain regions from three biobanks.
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