Physiological (Skin conductance) and Psychological (State-trait anxiety) measures of anxiety were employed to assess the level of anxiety in 10 anxious neurotics, 10 schizophrenics and 10 normal subjects. Both the Physiological and Psychological measures were sensitive in detecting the level of anxiety in normals and patients. But interrelationships between these two measures were very poor.
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Mol Metab
January 2025
Peking-Tsinghua Center for Life Sciences, Beijing, China 100871; PKU-IDG/McGovern Institute for Brain Research, Beijing, China 100871; School of Psychological and Cognitive Sciences, Peking University, Beijing, China 100871; Beijing Key Laboratory of Behavior and Mental Health, Beijing, China 100871; Biosciences and Nutrition Unit, Department of Medicine Huddinge, Karolinska Institute, Huddinge, Sweden 14183. Electronic address:
The capacity of mature adipocytes to de-differentiate into fibroblast-like cells has been demonstrated in vitro and a few, rather specific in vivo conditions. A detailed comparison between de-differentiated fat (DFAT) cells and adipose stem and progenitor cells (ASPCs) from different adipose depots is yet to be conducted. Moreover, whether de-differentiation of mature adipocytes from classical subcutaneous and visceral depots occurs under physiological conditions remains unknown.
View Article and Find Full Text PDFPsychoneuroendocrinology
December 2024
First Department of Psychiatry, Eginition Hospital, National and Kapodistrian University of Athens, 72-74 Vas. Sophias Ave, Athens 11528, Greece.
Despite considerable social progress, transgender people still face multiple chronic stressors. This study evaluated the allostatic load index and assessed specific psychological characteristics between transgender and cisgender participants who were matched based on age and assigned-at-birth gender. Twenty-one transgender people (52.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
February 2025
Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218.
The hippocampal dentate gyrus (DG) is thought to orthogonalize inputs from the entorhinal cortex (pattern separation) and relay this information to the CA3 region. In turn, attractor dynamics in CA3 perform a pattern completion or error correction operation before sending its output to CA1. In a mouse model of congenital hypoplasia of the DG, a deficiency in the (Wls) gene, specifically in cells expressing , which targets neuronal progenitors, led to an almost total absence of dentate granule cells and modestly impaired performance in spatial tasks.
View Article and Find Full Text PDFHeart Fail Rev
January 2025
Centre d'Investigations Cliniques Plurithématique 1433 and INSERM U1116, CHRU Nancy, FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Institut Lorrain du Coeur Et Des Vaisseaux, CHRU de Nancy, Université de Lorraine, Nancy, France.
Mineralocorticoid receptor antagonists (MRAs) are a cornerstone of guideline-directed medical therapy for heart failure with reduced ejection fraction (HFrEF), offering significant benefits in reducing mortality and hospitalizations. However, their use is often constrained by the risk of hyperkalemia, particularly in patients with chronic kidney disease. Patiromer and sodium zirconium cyclosilicate (SZC), two novel potassium binders, have emerged as highly effective and safe tools for managing hyperkalemia and enabling the optimization of MRA therapy.
View Article and Find Full Text PDFBrain Behav Immun Health
December 2024
Justus-Liebig University Giessen, Germany.
Functional cognition is relevant for athletic success and interdependent with physical exercise, yet despite repeatedly demonstrated inflammatory responses to physical training, there are no studies addressing the relationship between cognition and inflammation in athletes. The aim of this study was to investigate the relationship between cognitive performance and selected inflammatory, and further physiological biomarkers in elite athletes. Data from 350 elite athletes regarding cognitive performance (processing speed, selective attention, working memory, cognitive flexibility), systemic inflammatory markers, metabolic hormones, growth factors, tissue damage markers, and micronutrients (e.
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