The pathological process due to Coxsackie A18 virus and hemolytic streptococcus infection was studied in adult white mice. Their synergistic effect was established as manifested by longer periods of virus detection in the blood and heart and the detection of the streptococcus in animals infected with an 8-fold lower dose. In cases of combined infection, signs of dystrophy, destruction and proliferation developed in the myocardium reaching the highest intensity when the virus and the microbe had been inoculated simultaneously.
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