AI Article Synopsis
- The study aimed to evaluate the outcomes of fertility-sparing treatments in young women (≤40 years) with epithelial ovarian carcinoma (EOC).
- A retrospective analysis involved 94 patients who underwent fertility-sparing surgery, revealing that higher histologic grades were associated with decreased overall and disease-free survival.
- The findings suggest that fertility-sparing treatment may be an option for early-stage EOC patients, as most women resumed normal menstruation post-chemotherapy and several achieved pregnancies by the end of the study.
Article Abstract
Objective: To assess the clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma (EOC).
Methods: A retrospective study of young EOC inpatients (≤40 years old) was performed during January 1994 and December 2010 in eight institutions.
Results: Data were analyzed from 94 patients treated with fertility-sparing surgery with a median follow-up time of 58.7 months. As histologic grade increased, overall survival (OS) and disease-free survival (DFS) of patients receiving fertility-sparing surgery declined. Neither staging surgery nor laparoscopy of early stage EOC with conservative surgery had a significant effect on OS or DFS. Normal menstruation recommenced after chemotherapy in 89% of the fertility-sparing group. Seventeen pregnancies among twelve patients were achieved by the end of the follow-ups.
Conclusions: Fertility-sparing treatment for patients with EOC Stage I Grade 1 could be cautiously considered for young patients. The surgical procedure and surgical route might not significantly influence the prognosis. Standard chemotherapy is not likely to have an evident impact on ovarian function or fertility in young patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190093 | PMC |
| http://dx.doi.org/10.1631/jzus.B1100166 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!