Landau-Kleffner syndrome (LKS) is a childhood disorder characterized by an acquired aphasia that emerges in association with epileptiform electroencephalographic abnormalities. The language loss is often characterized by a severe disturbance of auditory language comprehension (verbal auditory agnosia) combined with a substantial disruption of expressive language. Comorbid behavioral disturbances commonly involve hyperactivity and attentional problems but sometimes encompass a more pervasive pattern of difficulties resembling an autism spectrum disorder. Now one the most frequently described forms of acquired aphasia in children, LKS has had a profound influence on both neurological practice and cognitive neuroscience. Here, we review current conceptualizations of LKS, consider its pleomorphic manifestations and discuss existing and future diagnostic issues and dilemmas. The potential relevance of LKS to understanding other disorders, including autistic regression, is considered.
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Article Synopsis
- - Landau-Kleffner syndrome (LKS) is a rare condition causing language regression and abnormal EEG patterns; early recognition and intervention are crucial for effective management.
- - A case study of an 8-year-old girl with language regression and suspected hearing loss revealed EEG abnormalities consistent with LKS, and treatment with speech therapy and valproic acid led to significant improvements.
- - The report emphasizes the need for a multidisciplinary approach involving various specialists to diagnose and manage LKS, and calls for more research to improve treatment and outcomes for affected children.
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