Neural tissue simulation extends requirements and constraints of previous neuronal and neural circuit simulation methods, creating a tissue coordinate system. We have developed a novel tissue volume decomposition, and a hybrid branched cable equation solver. The decomposition divides the simulation into regular tissue blocks and distributes them on a parallel multithreaded machine. The solver computes neurons that have been divided arbitrarily across blocks. We demonstrate thread, strong, and weak scaling of our approach on a machine with more than 4000 nodes and up to four threads per node. Scaling synapses to physiological numbers had little effect on performance, since our decomposition approach generates synapses that are almost always computed locally. The largest simulation included in our scaling results comprised 1 million neurons, 1 billion compartments, and 10 billion conductance-based synapses and gap junctions. We discuss the implications of our ultrascalable Neural Tissue Simulator, and with our results estimate requirements for a simulation at the scale of a human brain.
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http://dx.doi.org/10.3389/fninf.2011.00015 | DOI Listing |
Sci Rep
January 2025
Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
Sympathetic nerves regulate nearly all human organs. Their peripheral nerves are present in tumor tissue. Activation of the sympathetic nervous system promotes malignant transformation in several cancers.
View Article and Find Full Text PDFJ Imaging Inform Med
January 2025
Ear, Nose and Throat Department, Batman Training and Research Hospital, Batman, Turkey.
Adenoid hypertrophy, characterized by the abnormal enlargement of adenoid tissue, is a condition that can cause significant breathing and sleep disturbances, particularly in children. Accurate diagnosis of adenoid hypertrophy is critical, yet traditional methods, such as imaging and manual interpretation, are prone to errors. This study uses an ensemble deep learning-based approach for adenoid classification.
View Article and Find Full Text PDFNo Shinkei Geka
January 2025
Tama Neurosurgery Clinic, Kanagawa.
Posterior cervical decompression surgery is safe and effective. It was developed to safely and reliably decompress nerve tissues. Maximising the reconstruction and maintenance of the posterior neck tissue has been reported and developed.
View Article and Find Full Text PDFToxicon
January 2025
USTHB, Faculty of Biological Sciences, Laboratory of Cellular and Molecular Biology, BP 32, El-Alia Bab Ezzouar, 16111 Algiers, Algeria; Algerian Academy of Sciences and Technology, Villa Rais Hamidou, Chemin Omar Kachkar, El Madania, Algiers, Algeria. Electronic address:
The immune response is increasingly being linked to the pathogenic processes underlying neurological disorders including potassium channel malfunction. Few investigations, meanwhile, have shown how cyclooxygenase-2 (COX-2) is involved in the neuroimmunopathology linked to potassium channel failure. Thus, using an animal model of neuropathology caused by kaliotoxin, an exclusive blocker of voltage-gated potassium channels from the scorpion venom of Androctonus australis hector, we examined the immunomodulatory impact of celecoxib (selective inhibitor of COX-2).
View Article and Find Full Text PDFJ Control Release
January 2025
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China. Electronic address:
Neurotrophic keratopathy is a degenerative disease caused by corneal nerve damage, leading to corneal ulceration. Recombinant human nerve growth factor (rhNGF) was approved for neurotrophic keratitis therapy; however, the excipients of the eye drops are not optimized for its controlled release. To this aim, we introduce the hypotonic hydrogel PF127 as an excipient for rhNGF in eye drops.
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