AI Article Synopsis
- Siderocalins are lipocalins that help the immune system by blocking bacteria from getting iron through their siderophores, and they play roles in inflammation, iron transport, tissue development, and cancer.
- The study focuses on siderocalin Q83, which can bind both enterobactin (a siderophore) and unsaturated fatty acids at the same time, indicating a unique dual binding capability.
- The findings suggest that Q83 acts as a connection between iron and fatty acid metabolism, potentially explaining the diverse roles of siderocalins in various processes.
Article Abstract
Siderocalins are particular lipocalins that participate in the innate immune response by interfering with bacterial siderophore-mediated iron uptake. Additionally, siderocalins are involved in several physiological and pathological processes such as inflammation, iron delivery, tissue differentiation, and cancer progression. Here we show that siderocalin Q83 displays an unexpected dual ligand binding mode as it can bind enterobactin and unsaturated fatty acids simultaneously. The solution structure of the siderocalin Q83 in complex with arachidonic acid and enterobactin reveals molecular details of this novel dual binding mode and the determinants of fatty acid binding specificity. Our results suggest that Q83 is a metabolic hub linking iron and fatty acid pathways. This unexpected coupling might contribute to the pleiotropic functions of siderocalins.
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| http://dx.doi.org/10.1021/bi201115q | DOI Listing |
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