The utility of P50 paired-click measures is limited by their unestablished reliability, unknown effects of time, and long protocol. This study measured within-session reliability, temporal course, effect of varying interpair interval (IPI), and peak definition and ratio calculation methods on P50 paired-click measures in healthy participants. Results indicate higher reliability for difference (ICC=.72) than ratio (ICC=.44) method; when P50 peaks are defined as baseline-to-peak than peak-to-peak; time-related changes; and comparable P50 paired-click measures at long (9 s) and short (3-7 s) IPIs. After controlling for time effects, P50 paired-click measures are relatively reliable within-session and are best measured using the difference method and defined as baseline-to-peak amplitude; time effects must be taken into account when measuring P50 paired-click measures in a long paradigm; and IPI can be shortened in studies with healthy samples.
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Novel N100 area reliably captures aberrant sensory processing and is associated with neurocognition in early psychosis.
Schizophr Res
September 2024
Department of Psychiatry, University of California, San Diego, United States of America. Electronic address:
Background: Despite findings from translational and genetic studies in the event-related potential (ERP) literature, the validity and reliability of P50 suppression as a schizophrenia spectrum endophenotype has been questioned. Here, we aimed to examine sensory registration and gating measures derived from P50 and N100 amplitude, as well as N100 area-a novel approach proposed herein-in early psychosis versus health.
Methods: Individuals at clinical high risk for psychosis (CHR; n = 77), first-episode psychosis (FE; n = 52), and healthy controls (HC; n = 65) were assessed in a paired-click auditory ERP paradigm.
Examining the impact of schizotypal personality traits on event-related potential (ERP) indexes of sensory gating in a healthy population.
Personal Neurosci
April 2023
Department of Psychiatry, Dalhousie University, Halifax, Canada.
Article Synopsis
- The study investigated the relationship between schizotypy traits and sensory gating ability in individuals with varying levels of schizotypy, using tests like the paired click paradigm.
- It found no significant differences in sensory gating between high and low schizotypy groups, suggesting that participants might have had issues with attention allocation instead.
- The research emphasizes the need to consider participants across the full spectrum of schizotypy and to include measures of related factors like impulsivity to better understand their effects on sensory processing.
Short-term transcutaneous trigeminal nerve stimulation does not affect visual oddball task and paired-click paradigm ERP responses in healthy volunteers.
Exp Brain Res
February 2023
Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100, Sassari, Italy.
Recent research suggests that transcutaneous trigeminal nerve stimulation (TNS) may positively affect cognitive function. However, no clear-cut evidence is available yet, since the majority of it derives from clinical studies, and the few data on healthy subjects show inconsistent results. In this study, we report the effects of short-term TNS on event-related potentials (ERP) recorded during the administration of a simple visual oddball task and a paired-click paradigm, both considered useful for studying brain information processing functions.
View Article and Find Full Text PDFAcute Stress and Gender Effects in Sensory Gating of the Auditory Evoked Potential in Healthy Subjects.
Neural Plast
November 2021
Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, Sichuan 610060, China.
Sensory gating is a neurophysiological measure of inhibition that is characterized by a reduction in the P, N, and P event-related potentials to a repeated identical stimulus. It was proposed that abnormal sensory gating is involved in the neural pathological basis of some severe mental disorders. Since then, the prevailing application of sensory gating measures has been in the study of neuropathology associated with schizophrenia and so on.
View Article and Find Full Text PDFExpanding our understanding of sensory gating in children with autism spectrum disorders.
Clin Neurophysiol
January 2021
Department of Occupational Therapy, Colorado State University, Fort Collins, CO 80523, USA; Department of Molecular, Cellular, and Integrative Neuroscience, Colorado State University, Fort Collins, CO 80523, USA. Electronic address:
Objective: This study examined sensory gating in children with autism spectrum disorders (ASD). Gating is usually examined at the P50 component and rarely at mid- and late-latency components.
Methods: Electroencephalography data were recorded during a paired-click paradigm, from 18 children with ASD (5-12 years), and 18 typically-developing (TD) children.
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