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Interactions between epithelial mesenchymal plasticity, barrier dysfunction and innate immune pathways shape the genesis of allergic airway disease.
Expert Rev Respir Med
January 2025
School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA.
Introduction: In genetically predisposed individuals, exposure to aeroallergens and infections from RNA viruses shape epithelial barrier function, leading to Allergic Asthma (AA). Here, activated pattern recognition receptors (PRRs) in lower airway sentinel cells signal epithelial injury-repair pathways leading to cell-state changes [epithelial mesenchymal plasticity (EMP)], barrier disruption and sensitization.
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This sequential mixed-methods study examines how Americans ascribe meanings to the concepts , , and . We first conduct interviews ( = 40) using a symbolic boundaries elicitation approach, gathering examples of scenarios that do and do not "count" as racism, sexism, and classism. We then use these examples as vignettes in a nationally representative survey experiment ( = 2,000).
View Article and Find Full Text PDFMotivations for obtaining advance provision of medication abortion in the United States: a qualitative study.
BMJ Sex Reprod Health
December 2024
Lyndon B. Johnson School of Public Affairs, University of Texas at Austin, Austin, Texas, USA.
Background: Advance provision of medication abortion, or the prescription of mifepristone and misoprostol before pregnancy occurs, is an unexplored care model aimed at expanding abortion access. We examine motivations for obtaining advance provision from the online telemedicine service, Aid Access, which supports people in the United States.
Methods: Between May and November 2023, we conducted semi-structured, in-depth interviews with 39 people who obtained advance provision between January 2022 and April 2023.
Pediatric Organ Donation, Transplantation, and Updated Brain Death Criteria: An Overview for Pediatricians.
Pediatr Rev
January 2025
Department of Pediatrics, Division of Pediatric Critical Care Medicine, University of Florida College of Medicine-Jacksonville, Florida.
Pediatricians follow patients longitudinally and hold a unique position to address multiple issues, medical and psychosocial, that affect organ donation and transplantation. They are wellpositioned to provide anticipatory guidance during well-child visits and during care for children with end-stage organ failure and can either assist these patients with ongoing medical management or refer these patients for organ transplantation assessment. A pediatrician's trusted relationship with families and patients allows for guidance on medical and ethical issues surrounding brain death, organ donation, and transplantation.
View Article and Find Full Text PDFAmericans' support for future pandemic policies: insights from a national survey.
Health Aff Sch
December 2024
The de Beaumont Foundation, Bethesda, MD 20814, United States.
The arrival of bird flu (H5N1) is a poignant reminder of the need for public health leaders to understand Americans' evolving perspectives on pandemic mitigation policies. To guide response efforts, we conducted a nationally representative opinion survey among 1017 U.S.
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